基于离散单元法多孔陶瓷微球骨支架的微观结构分析

Research of Artificial Bone Material Microstructure Based on Discrete Element Method

人工骨支架的孔隙率是评价体液在人工骨内部循环和细胞生长能力的重要参数,利用离散单元法分析模拟人工骨支架制备过程中HA微球的堆积过程,实现了对堆积内部微观情况的预测。本文以PFC3D软件为平台对HA石微球人工骨支架的微观结构进行了模拟仿真,从而通过改变HA微球和可速溶性小球的数量比及半径值,实现孔隙率可控,得出配位数为6时,HA微球人工骨支架的孔隙率为0.59,在满足力学性能的条件下,与人骨组织的孔隙率最为接近。

The porosity of artificial bone scaffold is an important parameter that affects the fluid circulation in bone cells and internal growth capacity in the body. In the artificial bone scaffold fabrication process, using discrete element method to simulate the accumulation of HA microspheres, realize the internal microstrueture prediction of accumulation. Simulating the artificial bone scaffold microstructure based on the platform of PFC3D software. Thus by changing the number ratio and radius of HA mierospheres and soluble balls, achieve the porosity is controllable. Have obtained that the porosity of HA microsphere artificial bone scaffold is 0.59, meanwhile the coordination number is 6.