阿托伐他汀对充血性心力衰竭患者肾素-血管紧张素-醛固酮系统及红细胞参数的影响

Influence of atorvastatin on the renin-angiotensin-aldosterone system and erythrocyte parameters in patients with congestive heart failure

目的探讨阿托伐他汀对充血性心力衰竭患者肾素-血管紧张素-醛固酮系统及红细胞参数的影响。方法选取2011年9月至2012年12月于本院进行治疗的78例充血性心力衰竭患者为研究对象,将78例患者随机分为对照组和观察组各39例,对照组按照常规治疗方案进行干预,观察组则在常规治疗方案的基础上加用阿托伐他汀,然后将两组患者治疗前与治疗后4周、8周、12周的肾素-血管紧张素-醛固酮系统及红细胞参数水平进行对比。结果观察组治疗后4周、8周、12周的肾素-血管紧张素-醛固酮系统及红细胞参数水平均明显优于治疗前,并且显著优于对照组治疗后4周、8周、12周的水平,差异均有统计学意义(P<0.05)。结论阿托伐他汀可显著地降低充血性心力衰竭患者肾素-血管紧张素-醛固酮系统及红细胞参数水平,更有利于调整患者的整体血供及循环状态。

Objective To study the influence ofatorvastatin on the renin-angi system and erythrocyte parameters in patients with congestive heart failure. Methods Seventy-eight patients with congestive heart failure who were treated in our hospital from September 2011 to December 2012 were selected as research sub- jects. The patients were randomly divided into the control group and the observation group, with 39 cases in each group. Patients in the control group were treated with conventional therapeutic regimen, while those in the observation group were treated with atorvastatin based on the conventional therapeutic regimen. Then the renin-angiotensin-aldo- sterone system and erythrocyte parameters before treatment and at the 4~, 8~ and 12~ week after treatment were com- pared between the two groups. Results The renin-angiotensin-aldosterone system and erythrocyte parameters in the observation group at the 4＊, 8~ and 12＊ week after treatment were all significantly better than those before treatment, and the levels were all significantly better than those in the control group at 4＊, 8＊ and 12~ week after treatment, all P〈 0.05. Conclusion Atorvastatin can significantly decrease the renin-angiotensin-aldosterone system and erythrocyte parameters in patients with congestive heart failure, and it is more beneficial for the adjustment of whole blood supply and circulation.