摘要
目的观察注射用香菇多糖联合DCF(多西紫杉醇+顺铂+氟尿嘧啶)方案治疗胃癌的免疫调节作用及毒副反应。方法将经病理学及影像学确诊为胃癌的患者44例作为研究对象,其中术后20例,复发转移24例,随机分为注射用香菇多糖联合DCF方案组(联合治疗组)22例及单纯DCF方案组(对照组)22例。每例患者每治疗2个周期,进行疗效评价。结果联合治疗组可评价疗效22例,治疗后T细胞总数(CD3+)、T辅助细胞(CD4+)的数量及CD4+/CD8+比值均较治疗前增加(P<0.05)。而对照组治疗后T辅助细胞(CD4+)的数量有所降低(P<0.05),T细胞总数及CD4+/CD8+比值无明显变化。联合治疗组白细胞减少的发生率为63.64%,恶心呕吐发生率为59.09%,显著低于对照组白细胞减少(90.91%)及恶心呕吐发生率(86.36%),差异有统计学意义(P<0.05)。黏膜损害、腹泻及肝肾功能损害等不良反应的发生两组差异无统计学意义。结论注射用香菇多糖能够增加胃癌患者的免疫功能,减少DCF方案化疗的毒副作用,增加患者化疗耐受性。
Objective To observe the immune regulation efficacies and toxicities oflentinan injection com- bined with DCF regimen (docetaxel + cisplatin + fluorouracil) in the treatment of patients with gastric carcinoma. Methods Forty-four patients with gastric carcinoma diagnosed by histopathology, cytlogy and imaging, the postoper- ative of 20 cases, recurrence and metastasis of 24 cases, were divided into two groups. They were treated with DCF regimen alone (control group, n=22) or combination with lentinan injection (combination treatment group, n=22), and every patient received at least 2 cycles of the treatment. Results Twenty-two cases could be evaluated in combina- tion treatment group and 22 cases could be evaluated in control group. The immunological function detection showed that CD3~, CD4+, CD4~/CD~~ increased obviously post-therapy than pre-therapy in the combination treatment group (P〈0.05) and CDC decreased after treatment (P〈0.05). CD4+ decreased after treatment in the control group (P〈 0.05), another immunological functions had no difference between post-therapy and pre-therapy in the control group. The incidence of lencopenia and gastrointestinal reactions in combination treatment group were 63.64% and 59.09%. These incidence rates were significantly lower than those in the control group (P〈 0.05). Conclusion Lentinan injec- tion combined with DCF chemotherapy can improve the immunological function of the patients and obviously plays a supporting and synergistic effect in the treatment of gastric cancer, with fewer side effects.
出处
《海南医学》
CAS
2013年第24期3610-3612,共3页
Hainan Medical Journal
基金
南京医科大学科技发展基金面上项目(编号:08NMUM022)
关键词
注射用香菇多糖
化疗
胃癌
Lentinan injection
Gastric carcinoma
Chemotherapy