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HPV E6/E7 mRNA检测与病理组织学检查相结合在宫颈病变诊断中的应用价值 被引量：1

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摘要 目的探讨HPV E6/E7mRNA检测在宫颈病变诊断中的应用价值。方法选取2013年1—6月液基细胞学检测为ASCUS的患者130例,行组织病理学检查,同时应用b-DNA技术对组织学蜡块进行HPV E6/E7mRNA检测。结果 HPV E6/E7mRNA检测低危风险24例(病理组织学正常1例,CIN1级23例);中危风险22例(CIN1级9例,CIN2级13例),高危风险11例(CIN2级4例,CIN3级6例,宫颈鳞癌1例),阳性率43.8%,病理组织学诊断CIN2级以上病变24例,相应HPV E6/E7mRNA检测均为中危以上风险。经统计学分析,差异有统计学意义(P<0.05)。结论 HPV E6/E7mRNA含量可以更好地反应致癌基因的活动程度,具有更高的敏感性及特异性,可以直观的评估宫颈癌的发病风险及预后,同时对于组织学阴性或较低级别的病理组织学起到预测疾病发生的作用。
作者 赵春兰 张会辰 李丽 陈静
机构地区 河北省保定市妇幼保健院
出处 《中国煤炭工业医学杂志》 2013年第12期2007-2008,共2页 Chinese Journal of Coal Industry Medicine
关键词 人乳头瘤病毒 HPV E6 E7 mRNA b—DNA技术
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献8

  • 1Syrjanen S, Shabalove IP, Petrovichev N, et al. Hu- man papillomavirus testing and conventional Pap smear cytology as optional screening tools of women at different risks for cervical cancer in countries of the former Soviet Union[J]. J Low Genit Tract Dis, 2002,6 : 97.
  • 2Goldberg RM, Meropol NJ, Tabernero J, et al. Ac- complishments in 2008 in the treatment of advaffced metastatic colorectal cancer[J]. Gastrointest Cancer Res,2009,3(Suppl 2) :S23- S27.
  • 3Kraus I,Molden T, Holm R,et al. Presence of E6 and E7 mRNA {rom human papillomavirus types 16,18, 31,33,and 45 in the majority of cervical carcinomas [J]. J Clin Microbiol, 2006,44 : 1310 - 1317.
  • 4Molden T, Kraus I,Karlsen F, et al. Human papillo- mavirus E6/E7 mRNA expression in women younger than 30 years of age[J]. Gynecol Oncol,2006,100:95 - 100.
  • 5刘军,罗淑贞,卢义生,付莉萍,郭健.液基细胞学应用于宫颈癌筛查的研究[J].中国实用妇科与产科杂志,2004,20(9):553-554. 被引量：78
  • 6陆敏华,印永祥,黄望珍,赵华.465例宫颈液基细胞学与病理组织学检查结果对照分析[J].齐齐哈尔医学院学报,2010,31(11):1715-1715. 被引量：2
  • 7郎景和.迎接子宫颈癌预防的全球挑战与机遇[J].中华妇产科杂志,2002,37(3):129-131. 被引量：884
  • 8Hovland S, Muller S, Skomedal H, et al. E6/E- 7mRNA expression analysis a test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure[J]. Int J Oncol,2010,36 : 1533 - 1539.

二级参考文献11

  • 1刘军,罗淑贞,卢义生,付莉萍,郭健.液基细胞学应用于宫颈癌筛查的研究[J].中国实用妇科与产科杂志,2004,20(9):553-554. 被引量：78
  • 2Solomon D,Davey D,Kunnan R,et al.The 2001 Bethesda system:terminology for reporting results of cervical cytology[J].The Journal of American Medical Association,2002,287(16):2 114-2 119.
  • 3Kreuger FAF,Beerman H.The screening of women with cervical cancer of the Rotterdam area[J].Eur J Epidemio,2000,16(7):641-645.
  • 4Kontzoglou K,Moulakakis KG,Alexiou D,et al.The role of liquid-based cytology in the investigation of colorectal lesions:a cytohistopathological correlation and evaluation of diagnostic accuracy[J].Langenbecks Arch Surg,2007,392(2):189-195.
  • 5Deshou H,Changhua W,Qinyan L,et al.Clinical utility of Liqui-PREP? cytology system for primary cervical cancer screening in a large urban hospital setting in China[J].Journal of cytology,2009,26(1):20-25.
  • 6Andrawiss M.Cervial cancer vaccines available in 2007[J].Drug Discov Today,2005,10(14):949-950.
  • 7Frable WJ,Austin RM,Collins RJ,et al.Medicolegal affairs:IAC task force summary.Acta Cytol,1998,42(1):76-119
  • 8Lee KR,Ashfaq R,Birdsong GG,et al.Comparison of conventional Papanicolaou smears and a fluid-based thirrlayer system for cervical cancer screening.Obstet Gynecol,1997,90(2):278-284
  • 9Papillo JF,Zarka MA,St John TL.Evaluation of the Thinprep Paptest in clinical practice:a seven-month,16,314-case experience in northern Vermont.Acta Cytol,1998,42(1):203-208
  • 10Tezuka F,Shuki H,Oikawa H,et al.Numerical counts of epithelial cells collected,smeared and lost in the conventional Papanicolaou smear preparation.Acta Cytol,1995,39(3):837-838

共引文献943

同被引文献13

  • 1Arbyn M , Castellsague X, de Sanjose S, et al. Worldwide burden of cervicalcancer in 2008 [ J ]. Ann Oneol, 2011,22 (12) :2675- 2686.
  • 2曹泽毅.中华妇产科学[J].2版.北京:人民卫生出版社,2004:1848—1852,2012—2028.
  • 3Martin J L, Baxter R C. Signalling pathways of insulin like growthfactors (IGFs) and IGF binding protein 3 [ J ]. Growth Factors, 2011,29(6) :235-244.
  • 4Mdnikow J, Nuovo J, Willan A R, et al. Natural history of cervical squamous intraepithelial lesions: a meta-analysis [ J]. Obstet Gynecol, 1998,92:727-735.
  • 5Gage J C, Katki H A, Schiffman M, et al. The low risk of precancer after a screening result of human papillomavirus- negative/atypical squamous cells of undetermined signifi-cance papanicolaou and implications for clinical manage- ment [ J ]. Cancer Cytopathol, 2014,122 ( 11 ) :842-850.
  • 6Arbyn M, Sasieni P, Meijer C J, et al. Clinical applica- tions of HPV testing: a su mmary of meta-analyses [ J ]. Vaccine, 2006, 24( Suppl 3) :78-89.
  • 7Li C D, Wu M H, Wang J D, et al. A population based study on the risks of cervical lesion and human papilloma- virus infection among women in Beijing, people's Republic of China [ J ]. Cancer Epidem Biomarm, 2010, 19 ( 10 ) : 2656- 2664.
  • 8Trop A, Sjcborg K D, Nyg hrd M, et al. Cytology and hu- man papillomavirus testing 6 to 12 months after ASCUS or LSIL cytology in organized screening to predict high-grade cervical neoplasia between screening rounds [ J ]. J Clin Mi- crobiol, 2012,50(6) : 1927- 1935.
  • 9Castle P E, Cox J T, Jeronimo J, et al. An analysis of high-risk human papillomavirus DNA-negative cervical pre- cancers in the ASCUS-LSIL Triage Study (ALTS) [ J ]. Ob- stet Gynecol, 2008,111 (4) : 847-856.
  • 10Coupe V M, Berkhof J, Bulkmans N W, et al. Age-de-pendent prevalence of 14 high-risk HPV types in the Neth- erlands: implications for prophylactic vaccination and screening[J]. Br J Cancer, 2008,98(3) :646-651.

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二级引证文献16

中国煤炭工业医学杂志
2013年 第12期

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