钆喷酸葡胺注射液不良反应的文献分析

Literature Analysis on the Adverse Drug Reactions of Gd-DTPA

目的分析钆喷酸葡胺注射液发生不良反应特点及相关因素，为临床合理用药提供参考。方法对万方数据库2002～2012年发表的文献进行检索，对涉及钆喷酸葡胺注射液不良反应病例的信息进行分类统计分析。结果发生不良反应的男女比例为1：1．2，多数不良反应发生在用药后30min内。非过敏反应有59例（44％）；轻度过敏性反应有47例（35％）；中度过敏性反应10例（8％）；重度过敏性反应18例（13％），其中死亡有6例（4％）。结论虽然钆喷酸葡胺注射液不良反应发生率较低，但仍可引起严重的过敏反应，甚至休克死亡，由于其使用多在缺少临床医护监护的影像诊断科，所以更应加强其监测。

Objective To explore the situation and rules of adverse drug reactions of Gd-DTPA injection, in order to provide reference for the rational use of drugs in clinic. Methods We collected the literatures related to the adverse reactions of Gd-DTPA injection in WANFANG Database from 2002 to 2012, and conducted a statistical analysis. Results The results showed that the ratio of male to female was 1：1.2. Most adverse reactions occurred whthin 30 minutes after medication. There were 59 cases（44%） of non-allergic reactions, 47 cases（35%） of mild allergic reactions, 10 cases（8%） of moderate allergic reactions,18 cases（13%） of severe allergic reactions,of which 6 cases（4%） died. Conclusion In spite of Gd-DTPA injection with low incidence of adverse reaction, it can still cause severe allergic reactions and even death. Pharmacists should strengthen the monitoring because of its use in imaging diagnosis without clinical care.