北京丰台区女性人乳头瘤病毒感染及分型

Human papillomavirus infection and genotyping in female in Fengtai Dis- trict of Beijing

目的了解北京市丰台区女性人乳头瘤病毒(HPV)感染情况及基因型,以及其与生殖道疾病的关系。方法对2012年9月1—30日在某院妇科就诊的673例女性生殖道疾病患者进行HPV检测,比较不同基因型HPV与女性生殖道疾病类型的关系。结果 673例患者中检出HPV阳性140例(20.80%);宫颈炎、宫颈病变、宫颈癌和其他炎症(包括外阴炎、阴道炎、盆腔炎和泌尿系感染)患者HPV检出率分别为23.32%(87例)、38.89%(14例)、61.11%(11例)和11.38%(28例)。140例HPV阳性患者(197例次)共检出13种HPV亚型(52、16、58、56、39、51、68、33、59、18、31、35、45型),其中HPV52型所占比率(18.78%)最高,其次是HPV16(16.75%)和HPV58型(11.67%)等;单一感染103例(73.57%),二重及多重感染37例(26.43%),HPV阳性的宫颈癌患者均为二重感染。结论该地区女性生殖道疾病患者HPV感染及型别分布有地区特异性。了解本地区HPV感染及型别分布,为探索及有效防治HPV相关疾病提供了流行病学资料。

ObjectiveTo investigate distribution and genotypes of human papillomavirus （HPV） infection，as well as relationship between HPV infection and female genital diseases in Fengtai District of Beijing.MethodsHPV detection was performed among 673 female patients with genital diseases in an outpatient department from September 1 to 30, 2012, the relationship between HPV genotypes and genital diseases was analyzed.Results Of 673 patients, 140（20.80%） were with positive HPV test; HPV detection rate in patients with cervicitis, cervical lesions, cervical cancer,and other inflammatory diseases （including vulvitis, vaginitis, pelvic inflammatory disease, and urinary tract infection）was 23.32%（87 cases）,38.89%（14 cases）,61.11%（11 cases）, and 11.38%（28 cases） respectively. 140 patients were detected 197 times of HPV, 13 subtypes were included（type 52,16,58、56,39,51,68,33,59,18,31,35,and 45）, the top three HPV types were ranked by HPV52（18.78%）, HPV16（16.75%） and HPV58 （11.67%）; Incidence of singleinfection was 73.57% （103 cases）,double and multiple infection was 26.43%（37 cases）, all HPVpositive patients with cervical cancer had double infection.ConclusionThe incidence and types of HPV infection in local female patients are regionally distributed. Survey on the incidence and distribution can provide epidemiological data for exploring effective prevention and therapy for HPVrelated diseases.