医院254例药物不良反应分析’

Analysis of 254 reports of adverse drug reaction

目的分析探讨北京中医药大学东方医院药物不良反应（ADR）发生情况，为临床合理用药及药物安全性评价提供依据。方法收集2012年1—12月北京中医药大学东方医院上报至北京市ADR监测中心的254例ADR病历资料，并进行回顾性分析。将所收集的ADR病历资料按患者年龄、性别、既往史、疑似不良反应药物的种类、给药途径等情况的相关例数及构成比进行分析。结果254例患者发生ADR共316例次，老年患者137例（53．9％），有既往史者44例（17．3％），静脉滴注218例次（69．0％）。疑似西药中，以抗微生物类药物为主，占37．7％（119例次）。结论应加强ADR监测意识，促进临床合理用药，减少ADR的发生。

Objective To analyze the adverse drug reactions （ADR） and to provide a basis for reasonable use of drug in clinics and for evaluation of drug safety. Methods The 254 ADR cases submitted to Beijing ADR monitoring center by Beijing University of Chinese Medicine, Dongfang Hospital were analyzed, including age, gender, past medical history, types of drugs suspected, route of medicationetc. Results All 318 cases of ADR occurred to 254 patients, there were 137 old people（53.9% ）, 44 patients with past medical history（ 17.3% ）. 218 patients had intravenous drips conducted （ 69.0% ）. There were 119 antimicrobial drugs （ 37.7% ）. Conclusion We should enhance the awareness of monitoring ADR and improve clinical rational drug use to reduce the occurrence of ADR.