摘要
目的探讨罗哌卡因在犬坐骨神经阻滞时的药代动力学特点。方法选取健康杂种犬12只,按取血样本分为动脉组和静脉组,每组6只。动脉组取动脉血,静脉组取静脉血。2组肌内注射3%戊巴比妥钠30mg/kg麻醉后,分别采用0.5%罗哌卡因10mg/kg行单次坐骨神经阻滞,于罗哌卡因给药前,给药后10、20、30、40、60、90、120、150、180、240、360、720min分别抽取股动、静脉血5ml,采用反相高效液相色谱法测定血浆罗哌卡因浓度。计算药代动力学[分布半衰期(t1/2α)、消除半衰期(t1/2β)、达峰时间(Tmax)、峰值浓度(Cmax)、曲线下面积(AUC)、一阶矩曲线下面积(AUMC)、平均吸收时间(MAT)、平均残余时间(MRT)]参数。结果2组罗哌卡因阻滞犬坐骨神经时的血药浓度-时间曲线符合二室模型,t1/2α、t1/2β,Tmax,Cmax、AUC0-720min、AUC0-∞、AUMC0-72min、AUMC0-∞、MAT、MRT0-720min,MRT0-∞比较差异均无统计学意义(均P〉0.05)。结论动静脉血对罗哌卡因阻滞犬坐骨神经时的药代动力学无影响。
Objective To investigate the pharmacokinetics of ropivacaine in sciatic nerve block of dogs. Methods Twelve healthy adult mongrel dogs were divided into artery group and vein group and each group had 6 dogs. A polyethylene catheter was surgically inserted into the sheath of sciatic nerve for nerve block with ropivaeaine after anesthetized with intramuscular 3% pentobarbital 30 mg/kg. Femoral artery and vein was cannulated. 0.5% ropivacaine 10 mg/kg was injected into the sheath of sciatic nerve. Arterial or venous blood samples were taken for determination of plasma ropivacaine concentration (using HPLC) before and at 10, 20, 30, 60, 90, 120, 150, 180, 240, 360 and 720 rain after ropivacaine given. The pharmacokinetic parameters [ distribution of half-life (t1/2α) , elimination half-life (t1/2β) , time max (Tmax ), peak plasma concentration (Cmax), area under the curve (AUC) , area under the first moment of the plasma concentration-time (AUMC) , average absorption time (MAT) , average residual time (MRT) ] were determined. Results The concentration-time curve was fitted to a two-compartment open model in the two groups. No significant difference was found in t1/2α, t1/2β, Tmax, Cmax, AUCo-720 min, AUC0-∞ , AUMCo-720min, AUMC0- ∞, MAT, MRT0-720 min, MRT0- ∞between the two groups (all P 〉 0.05 ). Conclusion There is no significant difference between aterial and venous blood in ropivacaine pharmacokinetics.
出处
《中国医药》
2013年第12期1792-1793,共2页
China Medicine