多西他赛联合顺铂治疗晚期乳腺癌112例临床疗效观察

Clinical effect of docetaxel and cisplatin on advanced breast cancer

目的研究多西他赛联合顺铂治疗晚期乳腺癌的临床效果,为晚期乳腺癌的治疗提供临床参考。方法将2009年1月至2012年7月我院住院治疗的224例晚期乳腺癌患者采用随机数字表法分为2组,对照组给予多西他赛联合多柔比星进行治疗,治疗组患者采用多西他赛联合顺铂进行治疗,治疗结束后评价临床疗效及不良反应发生率。结果治疗组临床总有效率为55.4%,对照组临床总有效率52.7%,2组比较差异无统计学意义(P>0.05);2组患者的不良反应以中性粒细胞减少、恶心、呕吐为主,其中治疗组患者恶心、呕吐的发生率要明显低于对照组,差异有统计学意义(P<0.05)。结论多西他赛联合顺铂治疗晚期乳腺癌临床效果显著,患者总体耐受性较好,且引起的恶心、呕吐发生率更低,更适合体质较弱的患者。

Objective To study the clinical effect of docetaxel and cisplatin on advanced breast cancer. Methods Two hundred and twenty-four patients with advanced breast cancer from Jan, 2009 to July, 2012 were randomly divided into treatment group and control group~ all the patients were treated with basic therapy. And the patients in control group were treated with docetaxel and doxorubicin, the patients in treatment group was received with docetaxel and cisplatin. The clinical effect and adverse effect were compared after treatment. Results The total effective rate of treatment group was 55.4%, and the rate of control group was 52.7~. the differences were not statistically significant between the two groups（P^0.05）. The adverse effect in the two groups were neutro- penia, nausea and vomiting, the rate of nausea and vomiting were lower than control（P^0.05）. Conclusion Do- cetaxel and cisplatin shows satisfactory clinical efficacy in the treatment of breast cancer, of which the tolerance is lower. The rate of nausea and vomiting were low, and it is suitable for physique weaker patients, and we must pay attention in clinical application.