多磺酸粘多糖乳膏治疗婴儿湿疹临床疗效观察

The clinical observation on the efficacy of hirudoid for infantile eczema

目的:观察多磺酸粘多糖乳膏(商品名:喜辽妥)治疗婴儿湿疹的临床疗效及不良反应。方法:采用随机、开放、平行对照的方法将140例干燥型亚急性婴儿湿疹患儿分为2组,试验组和对照组分别外用喜疗妥乳膏和肝素钠乳膏,每天2次,疗程3周,观察2组患儿的治疗结果和不良反应。结果:试验组有效率75.3%,对照组有效率53.7%,治疗组有效率明显高于对照组,差异有统计学意义(P<0.01),2组均未见明显不良反应发生。结论:喜疗妥乳膏治疗干燥型亚急性婴儿湿疹临床疗效确切,安全性高。

Objective： To observe the clinical efficacy and safety of Hirudoid for infantile eczema. Methods： A randomized, open-label, parallel-group controlled study was conducted in 140 infants with dry sub-acute eczema. The patients in treat- ment group were given topical hirudoid cream twice daily for 3 weeks while controls treated with topical heparin sodium cream twice daily for 3 weeks. The efficiency and adverse effects were evaluated after the treatment. Results： The total effec- tive rate was significantly higher in treatment group than in controls （75.3% for treatment group and 53.7% for the controls, P〈 0.01）. No adverse reaction was observed in either group. Conclusions： Hirudoid cream is effective and safe for infantile dry sub-acute eczema.