急性时相反应及凝血/纤溶系统参与慢性荨麻疹发病的研究进展

Acute-phase Response and Coagulation/Fibrinolysis in the Pathogenesis of Chronic Urticaria

慢性荨麻疹的病因复杂且仍然未完全清楚。已有文献报道慢性荨麻疹患者部分急性时相标记物水平升高,提示急性时相反应有可能参与了慢性荨麻疹的发病;另一方面,已证实慢性荨麻疹患者内、外凝血途径激活,多种凝血因子水平升高,并与慢性荨麻疹症状严重程度相关;在多种疾病中,急性时相反应与凝血/纤溶功能关系密切。本文就急性时相反应及凝血/纤溶系统参与慢性荨麻疹发病的周内外研究现状与进展作一综述。

The exact pathogenic meehanism of chronic urticaria（CU） is complex and unclear. It has been shown that concentrations of circulating acute-phase response biomarkers are elevated in chronic urticaria, suggesting the involvement of acute-phase response in the development of CU. Recently, it has been demonstrated that the activation of the coagulation/fibrinolysis and the increased level of coagulation factors may be correlated with the disease severity. The association of acute-phase response with coagulation/fibrinolysis has been shown in many diseases. This review summarized the recent advances and developments of chronic urticaria about acute-phase response and coagulation/fibrinolysis.