NB-UVB联合卤米松治疗原发性皮肤淀粉样变病62例临床观察

Clinical Observation of Narrow-spectrum Midwave Ultra-violet Phototherapy Combined with Sicorten for Treating Primary Cutaneous Amyloidosis

目的观察窄谱中波紫外线(NB-UVB)联合卤米松局部外用治疗原发性皮肤淀粉样变病的临床疗效。方法将入选的120例原发性皮肤淀粉样变痛患者随机分为两组,治疗组62例,予窄谱中波紫外线联合卤米松局部外用;对照组58例,仅予局部外用卤米松治疗,在治疗第4,8和12周末时判定临床疗效。结果治疗第4,8和12周末时,治疗组有效率分别为48.39%,61.29%和79.03%,对照组分别为39.66%,48.28%和58.62%,两组比较差异均有统计学意义(P均<0.05)。结论窄谱中波紫外线联合卤米松局部外用治疗原发性皮肤淀粉样变病的疗效优于单用卤米松治疗。

Objective To evaluate the efficacy of narrow-spectrum midwave ultra-violet （NB-UVB） combined with sicorten on primary cutaneous amyloidosis. Methods One hundred and twenty cases with primary cutaneous amyloidosis were divided into two groups randomly. Sixty-two cases in the experimental group were treated by NB-UVB radiation combined with sicorten, and 58 cases in the control group were treated by sicorten alone. The clinical therapeutic effect was evaluated after 4,8,12 weeks＇ treatment. Results The effective rates on 4th, 8th and 12th week were 48.39% vs. 39.66% , 61.29% vs. 48.28% , 79.03% vs. 58.62% respec- tively. There was significant difference between the treatment group and the control（ P 〈0.05 ）. Conclusion The combination of NB-UVB phototherapy with sicorten is more effective than sicorten alone in the treat- ment of primary cutaneous amyloidosis.