胰腺癌神经浸润相关分子表达及作用的研究进展

Advances in research on the expression and role of molecules involved in perineural invasion in pancreatic cancer

胰腺癌具有神经周浸润(perineural invasion,PNI)的特性。PNI是胰腺癌疾病进展和预后不良的重要指标。国内外近年一系列研究表明,众多生物分子及细胞信号通路与胰腺癌的PNI及其疼痛有密切关系,其中研究较为深入的包括NGF-TrkA通路的激活、CX3CR1的刺激、基质金属蛋白酶(MMP)的上调和细胞外基质的降解、免疫异常等。并且,PNI和肿瘤继发性占位、对神经元的破坏和异常再生、新生血管等因素的综合作用是造成胰腺癌顽固性疼痛及不良预后的重要原因。目前,国际上以这些分子和信号通路为靶点进行了一系列研究,并取得了一定的进展,对治疗胰腺癌和控制疼痛起到了一定作用。

One of the hallmark of advanced pancreatic cancer is its ability of perineural invasion （PNI）, which predie~ its development and unfavorable prognosis~ Recent years, many studies have indicated that a variety of mo- lecdar and mtra：,-ellul^r signal pathways are correlated with PNI and associated p^n. ~me that ha^e been further studied include activation of NGF-TrkA signaling, Stimulation of ehemokines CX3CR1, up-regulation ofrnatrix met. （MMP）, degradation of extraeellular matrix （ECM）, and abnormality of immune system. PNI, secondary spaee by tumor damage of neurons by tumor ceils,, and angivgenesis all contribute to the pain that is difficult to allcvia by conventional anodyne. Nowadays, studies focus on targeting these signal pathways would improve treatment outcomes for patients with pancreatic cancer.