白细胞介素10—1082基因多态性与胃癌遗传易感性的Meta分析

Association between interleukin-10-1082 gene polymorphisms and susceptibility of gastric cancer： a meta analysis

目的系统分析中国人群白细胞介素10—1052（IL-10—1082）基因多态性与胃癌遗传易感性的关系。方法采用Cochrane系统评价方法，检索1966年至2012年Medline、Embase、Cochrane Library、中国生物医学文献数据库（CBM）、中国期刊全文数据库（CJFD）和中国科技期刊全文数据库（CSJD）等数据库，收集IL-10—1052基因多态性与中国人群胃癌易感性的病例对照研究。将纳入研究的胃癌患者作为胃癌组，健康人群作为健康对照组。由2名研究者独立提取数据和进行文献质量评价，综合评价IL-10—1082位点基因型GG与AA、AG与AA及等位基因G与A在中国人胃癌组与健康对照组中是否有差异。采用Q检验和，2对异质性进行定量分析。采用固定或随机效应模型合并数据。计数资料采用优势比（OR）及95％可信区间（95％CI）表示。结果共纳入13篇文献，累计样本量5252例，其中胃癌组患者2077例，健康对照组人群3175例。Meta分析结果显示：携带IL．10—1082基因型GG与AG患者，其胃癌发生风险率高于与携带IL-10—1082基因型AA患者（OR=1．76，95％CI1．33～2．33；OR=2．05，95％CI1．62～2．66，P〈0．05）；IL-10—1082基因型具有等位基因G的患者其胃癌发生风险率高于含等位基因A的患者（OR=1．67，95％CI1．31～2．13，P〈0．05）。结论中国人群IL-10—1082基因型GG、AG及等位基因G与胃癌发生有关。

Objective To assess the association between interleukin- 10-1082 （ IL- 10-1082） gene poly- morphisms and susceptibility of gastric cancer in the Chinese population. Methods Cochrane systematic evaluation was adopted for the analysis. Articles published in Medline, Embase, Cochrane library, CBM, CJFD and CSJD from 1966 to 2012 were retrieved. Case control studies on the correlation between the IL-10-1082 polymor- phism and gastric cancer in Chinese population were collected. Gastric cancer patients were in the gastric cancer group, and healthy individuals were in the control group. Two researchers extracted data and evaluated the quality of literatures independently. Meta analysis was performed to detect whether there were differences between the gastric cancer group and the control group about the distribution of genotypes of IL- 10-1082 gene （ GG, AA, AG, AA, alleles G and A）. The heterogeneity was analyzed using the Q test or 12 test. Fixed effect model or random effect model was adopted, and the results of the meta analysis were presented with odds ratio （OR） and 95% con- fidence interval （95 % CI）. Results Thirteen literatures including 5252 patients were included in the analysis. There were 2077 patients in the gastric cancer group and 3175 patients in the control group. The results of meta analysis showed that population with the genotypes GG and AG have higher risk of having gastric cancer when compared with population with the genotype AA （OR = 1.76, 95% CI 1.33-2. 33 ; OR = 2. 08, 95% CI 1.62-2. 66, P 〈 0.05 ）. Population with the allele G have higher risk of having gastric cancer when compared with population with allele A （ OR = 1.67, 95 % CI 1.31-2. 13, P 〈 0.05 ）. Conclusion The genotypes GG, AG and the allele G of IL- 10-1082 gene of the Chinese population are significantly associated with the increased risk of gastric cancer.