竹叶椒化学成分的研究

Chemical constituents from barks of Zanthoxylum planispinum

目的研究竹叶椒Zanthoxylum planispinum树皮的化学成分。方法采用硅胶柱色谱及制备液相等技术分离纯化竹叶椒树皮的化学成分,并利用波谱技术鉴定其结构。结果从竹叶椒树皮中分离得到11个化合物,分别鉴定为降白屈菜红碱(1)、得卡瑞花椒碱(2)、6-丙酮基-N-甲基-二氢得卡瑞花椒碱(3)、arnottianamide(4)、platydesmine(5)、4-甲氧基-1-甲基-2-喹诺酮(6)、β-[(3-甲氧基-1,3-二氧正丙基)胺基]苯丙酸甲酯(7)、3-O-阿魏酰基奎尼酸甲酯(8)、去-4′,4″-O-二甲基表望春花素(9)、柄果花椒素A(10)、竹叶椒素B(11)。结论化合物11为新化合物,命名为竹叶椒素B,化合物7为新的天然产物,其余化合物为首次从该植物中分离得到。

Objective To study the chemical constituents from the barks of Zanthoxylum planispinum. Methods The chemical constituents were isolated and purified by column chromatography and their structures were identified by spectral data. Results Eleven compounds were isolated from the barks of Z. planispinum. Their structures were identified as norchelerythrine （1）, decarine （2）, 6-acetonyl-N-methyl-dihydrodecarine （3）, amottianamide （4）, platydesmine （5）, 4-methyoxy-N-methylquinolin-2-one （6）, benzenepropanoic acid, β-[（3-methoxy-1, 3-dioxopropyl） amino] methyl ester （7）, 3-O-（E）-feruloyl quinic acid methyl ester （8）, de-4′, 4″-O-dimethylepimagnolin （9）, zanthpodocarpin A （10）, and biplanispin B （11）. Conclusion Compound 11 is a new compound named biplanispine B. Compound 7 is a new natural product and other compounds are isolated form this plant for the first time.