鼠神经生长因子治疗小儿重症病毒性脑炎的临床观察

Clinical Observation of Mouse Nerve Growth Factor in the Treatment of Children Severe Viral Encephalitis

目的:探讨鼠神经生长因子在小儿重症病毒性脑炎治疗中的应用。方法:采用回顾性分析方法,将46例重症病毒性脑炎患儿分成治疗组26例及时照组20例,对照组采用常规治疗,治疗组在此基础上加用鼠神经生长因子30μg,im,qd,疗程2用。比较两组患儿治疗效果和不良反应发生情况。结果:治疗组患儿意识恢复、肌力恢复、病理征消失时间明显短于对照组(P<0.01),有效率明显高于对照组(P<0.05)。两组患儿不良反应发生率差异无统计学意义(P>0.05),均未发生严重不良反应。结论:鼠神经生长因子用于小儿重症病毒性脑炎的辅助治疗,对改善症状、缩短病程有一定疗效。

Objective：To investigate the application of mouse nervous growth factor（mNGF） in the treatment of children severe viral encephalitis.Method：Clinical data of 46 cases of severe viral encephalitis were divided into the treatment group and control group.The control group underwent conventional therapy,while the treatment group was injected 30 u.g mNGF once daily additionally. The treatment duration was 2 weeks.Both the groups were evaluated hy the clinical curative effect and adverse reactions.Result：The treatment group had shortened course（P ＆lt; 0.01） in consciousness restoration,myodynamia restoration and pathological signs disappearance.The total curative rate and effective rate in the treatment group were both higher then those in the control group with significant difference（P ＆lt;0.05）.And the adverse reaction rate in the two groups showed no significant difference（P ＆gt;0.05）.Conclusion： Adjuvant therapy using mNGF in patients with severe viral encephalitis may help improving symptoms and shortening the course.