2010~2012年我院抗菌药应用与细菌耐药性分析

Analysis of Use and Resistance of Antibacterials in Hospitalized Patients of Our Hospital During 2010-2012

目的：分析我院住院患者抗菌药的使用情况及细菌分离和耐药性的变迁。方法：调取我院2010~2012年住院患者抗菌药的使用量,并计算用药频度（DDDs）,统计分析抗菌药使用情况;对同期临床分离的病原菌、耐药资料进行统计分析。结果：2010~2012年抗菌药DDDs和销售金额逐年下降,同期临床分离的常见病原菌以革兰阴性菌为主,三年均未检出耐万古霉素的金黄色葡萄球菌和粪肠球菌,近两年检出耐万古霉素的屎肠球菌;革兰阴性菌对抗菌药的耐药率呈下降趋势。结论：三年来随着抗菌药用量逐渐减少,细菌耐药率呈整体下降趋势,但大肠埃希菌耐药仍较严重,规范抗菌药的临床应用可减缓细菌耐药的趋势。

Objective：To analyze the use and resistance of antibacterials in the inpatients of our hospital.Method：The annual consumption of antibacterials in the inpatients of our hospital from 2010 to 2012 were collected,DDDs were calculated and used to analyze the application of antibacterials statistically.The clinical isolated pathogens and drug resistance information were analyzed statistically as well.Result：The annual consumption of antibacterials and DDDs showed a downward trend from 2010 to 2012.Gram-negative bacilli were predominant among the clinical isolated pathogens.Vancomycin-resistant Enterococcus faecium strains were found in the last two years,however,vancomycin-resistant staphylococus aureus and Enterococcus faecalis stranins were not found in 3 years.Drug resistance rate of gram-negative bacilli showed an upward tendency.Conclusion：With the gradually antimicrobial amount reduce,bacterial resistance rate shows an overall downward trend in 3 years.However,Escherichia coli resistance remains serious,and the standardization of clinical application of antimicrobials may slow down the bacterial resistance trend.