期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

阿尔茨海默病防治药物研究进展 被引量：3

下载PDF
导出
摘要 阿尔茨海默病（Alzheimer’s disease,AD）是一种中枢神经系统变性疾病,早期是隐匿性认知功能减退,在510年内发展成严重的记忆丧失、行为和人格改变、语言障碍、丧失独立生活能力,最终近似植物人状态,常因褥疮、肺炎等继发性感染死亡。AD发病率与年龄高度相关,60岁左右人群的发病率为1%,之后约每56年翻一番[1]。随着世界人口老龄化,AD成为社会广泛关注的问题。AD患者具有神经炎性斑、神经纤维缠结、神经纤维的串珠样变性和弥漫性斑等标志性病理学特征[2]。这些特征在疾病进程中的作用仍存在争议,但最终会导致内嗅区皮层、海马区、
作者 柯洪琴 纪昌娥 吴红菱 于慧斌
机构地区 湖北医药学院附属太和医院 湖北医药学院 湖北医药学院附属人民医院
出处 《中国药师》 CAS 2013年第12期1904-1907,共4页 China Pharmacist
关键词 阿尔茨海默病 预防策略 疾病修饰 药物治疗
分类号 R971 [医药卫生—药品]
  • 相关文献

参考文献10

  • 1Smith MA,Zhu XW,Tabaton M. Increased iron and free radical generation in preclinical alzheimer disease and mild cognitive impairment[J].Journal of Alzheimer's Disease,2010,(01):363-372.
  • 2Doody RS,Gavrilova SI,Sano M. Effet of dimebon on cognition,activities of daily living,behaviour,and global function in patients with mild-to-moderate Alzheimer's disease:a randomised,double-blind,placebo-controlled study[J].The Lancet,2008,(9634):207-215.doi:10.1016/S0140-6736(08)61074-0.
  • 3Corrada MM,Kawas CH,Hallfrisch J. Reduced risk of Alzheimer's disease with high folate intake:the Baltimore Longitudinal Study of Aging[J].Alzheimers Dement,2005,(01):11-18.
  • 4Sano M,Ernesto C,Thomas RG. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study[J].New England Journal of Medicine,1997,(17):1216-1222.
  • 5Ziegler-Graham K,Brookmeyer R,Johnson E. Worldwide variation in the doubling time of Alzheimer's disease incidence rates[J].Alzheimers Dement,2008,(05):316-323.
  • 6Stone JG,Casadesus G,Gustaw-Rothenberg K. Frontiers in Alzheimer's disease therapeutics[J].Ther Adv Chronic Dis,2011,(01):9-23.
  • 7McManus MJ,Murphy MP,Franklin JL. The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease[J].The Journal of Neuroscience,2011,(44):15703-15715.
  • 8徐淑君,刘桂兰.β淀粉样蛋白导致的线粒体损伤研究进展[J].生物化学与生物物理进展,2010,37(6):589-593. 被引量：19
  • 9Whitehouse PJ. Quality of life:the bridge from the cholinergic basal forebrain to cognitive science and bioethics[J].Journal of Alzheimer's Disease,2006,(3 Suppl):447-453.
  • 10Kaminsky YG,Marlatt MW,Smith MA. Subcellular and metabolic examination of amyloid-beta peptides in Alzheimer disease pathogenesis:evidence for Abeta(25-35)[J].Experimental Neurology,2010,(01):26-37.

二级参考文献28

  • 1Reddy P H. Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease. Exp Neurol, 2009, 218(2): 286- 292.
  • 2Swerdlow R H, Khan S M. The Alzheimer's disease mitochondrial cascade hypothesis: An update. Exp Neurol, 2009, 218(2): 308-315.
  • 3Aguzzi A, Haass C. Games played by rogue proteins inprion disorders and Alzheimer's disease. Science, 2003, 302(5646): 814- 818.
  • 4Gibson GE, StarkovA, Blass J P, et al. Cause and consequence:Mitochondrial dysfianction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases. Biochim Biophys Acta, 2010, 1802(1): 122-134.
  • 5Devi L, Prabhu B M, Galati D F, et al. Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer' s disease brain is associated with mitochondrial dysfunction. J Neurosci, 2006, 26(35): 9057-9068.
  • 6Petersen C H, Alikhani N, Behbahani H, et al. The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial crista. Proc Natl Acad Sci USA, 2008, 105(35): 13145-13150.
  • 7Hirai K, Alley G, Nunomore A, et al. Mitochondrial abnormalities in Alzheimer, disease. J Neurosci, 2001, 21(9): 3017-3023.
  • 8Eckert A, Hauptmann S, Scherping I, et al. Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Neurodegener Dis, 2008, 5(3-4): 157-159.
  • 9Kaminsky Y G, Kosenko E A. Effects of amyloid-beta peptides on hydrogen peroxide-metabolizing enzymes in rat brain in vivo. Free Radical Res, 2008, 42(6): 564-573.
  • 10Diana A, Simic G, Sinforiani E, et all. Mitochondria morphology and DNA content upon sublethal exposure to beta-amyloid (1-42) peptide. Coll Antropol, 2008, 32(1): 51-58.

共引文献18

同被引文献76

引证文献3

二级引证文献8

中国药师
2013年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部