盐酸戊乙奎醚对脓毒症致急性肺损伤患者呼吸功能的影响

Therapeutic effects of penehyclidine hydrochloride on the respiratory function of patients with acute lung injury induced by sepsis

目的:研究盐酸戊乙奎醚对脓毒症(Sepsis)所致急性肺损伤的的临床治疗效果。方法:选择脓毒症致急性肺损伤患者41例,随机分为实验组(n=21例)和对照组(n=20例)。对照组给予常规标准治疗,实验组在对照组的基础上每12h给予盐酸戊乙奎醚(长托宁,PHC)2mg,持续7d,分别于给药前、给药第5天、给药第7天,比较患者在氧合指数、肺损伤评分、呼吸力学及炎症指标等方面的变化及差异。结果:实验组在给药后第5天、第7天,氧合指数、肺损伤评分、呼吸力学参数和炎症反应方面较给药前均有明显改善(P<0.05),且与对照组比较,各时间点、各项参数变化差异均有统计学意义(P<0.05)。结论:临床上应用盐酸戊乙奎醚能够起到改善患者呼吸功能、抑制全身炎症反应综合征的作用,有效缓解脓毒症所致的急性肺损伤。

Objective：To study the clinical effects of Penehyclidine Hydrochloride （PHC） on Sepsis induced acute lung injury in clinical treatment. Method：41 patients with acute lung injury induced by sepsis were enrolled in this study and were randomly divided into Experimental group （n = 21） and Control group （n= 20 patients）. The control group received routine standard treatment alone,and the experimental group were given additional 2 mg of Penehyclidine Hydrochloride （PHC） on the basis of routine standard treatment every 12 hours for 7 days,respec- tively,the blood sample were collected and the respiratory parameters were recorded at the beginning of the PHC administration,5 days after PHC administration,and 7 days after drug administrafion, to compare changes in oxygenation,lung injury score, respiratory mechanics and inflammatory markers of the patients. Result：Compared with the beginning, 5 days and 7 days after administration of PHC, the oxygenation index,lung injury score, respiratory mechanics parameters and inflammatory reactions were significantly improved （P〈0.05）,and then compared with control group, for each time point and each parameters, the parameters mentioned above were improved and the differences were of statistically significance （P 〈 0. 05）. Conclusion： The clinical application of Penehyclidine Hydrochloride may play an important role in improvement of respiratory function,inhibition of systemic inflammatory response syndrome （SIRS）,so as to alleviate sepsis-induced acute lung injury effectively.