A new method for the synthesis of 3-hydroxymethylbenzofuran

A new method for the synthesis of 3-hydroxymethylbenzofuran

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摘要 A new one-step synthesis of 3-hydroxymethylbenzofuran, based on intramolecular cyclization of 2- （methoxymethyl）-2-（2＇-methoxymethyl-4＇-methylphenyl）-butanone I under diluted hydrochloric acid in THF, was developed. The mechanism for this process was investigated via chemical equilibrium shift of tautomer in acidic conditions. The applicability of this new method was studied further in this paper. A new one-step synthesis of 3-hydroxymethylbenzofuran, based on intramolecular cyclization of 2- （methoxymethyl）-2-（2＇-methoxymethyl-4＇-methylphenyl）-butanone I under diluted hydrochloric acid in THF, was developed. The mechanism for this process was investigated via chemical equilibrium shift of tautomer in acidic conditions. The applicability of this new method was studied further in this paper.

作者 Huan Luo Yan-Fei Liu Chun-Lei Zhang Yan Wang Gang Ni De-Quan Yu

机构地区 State Key Laboratory of Bioactive Substance and Function of Natural Medicines

出处《Chinese Chemical Letters》 SCIE CAS CSCD 2013年第12期1115-1117,共3页 中国化学快报（英文版）

基金 supported by the National Mega-Project for Innovative Drugs (No. 2012zx09301002-002) State Key Laboratory of Bioactive Substance and Function of Natural Medicines

关键词 3-Hydroxymethylbenzo furan derivatives Mechanism Tautomer 3-Hydroxymethylbenzo furan derivatives Mechanism Tautomer

分类号 O621.3 [理学—有机化学]

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Chinese Chemical Letters

2013年第12期

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A new method for the synthesis of 3-hydroxymethylbenzofuran

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