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2009-2012年心脑血管病医院呼吸道感染患者痰培养病原菌分布及耐药分析 被引量:5

Sputum Culture Pathogenic Bacteria,~)istribution and Drug Resistance Analysis of Patients with Respiratory Tract Infection in Cardio-cerebrovascular Disease Hospital 2009-2012
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摘要 目的分析2009年1月~2012年12月心脑血管病医院呼吸道感染患者临床细菌培养标本的病原菌分布及主要病原菌的耐药特点,为临床抗感染治疗提供参考依据。方法送检标本按需氧或兼性厌氧进行分离培养,鉴定用梅里埃细菌鉴定板条;药敏试验采用K-B法;耐甲氧西林金黄色葡萄球菌(MethicillinresistantStaphylococcusaureus,MRSA)、超广谱p内酰胺酶(Extended-spectrumplactamases,ESBL)均按全国临床检验操作规程操作。结果2009年~2012年共培养患者痰液标本5835株,培养出阳性标本为2375株,培养阳性检出率为40.70%。主要致病菌为大肠埃希菌、金黄色葡萄球菌、肺炎克雷伯菌、铜绿假单胞菌和嗜麦芽窄食单胞菌。金黄色葡萄球菌对青霉素高度耐药,对万古霉素和替考拉宁均敏感;大肠埃希菌和肺炎克雷伯菌对头孢呋辛、环丙沙星有很高的耐药率,对亚胺培南、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦有很高的敏感率;铜绿假单胞菌对庆大霉素、哌拉西林有很高的耐药率,对哌拉西林/他唑巴坦、环丙沙星、左氧氟沙星有很高的敏感率。结论细菌耐药性比较严重,应注意对抗生素的合理使用并加强细菌耐药性监测工作。 Objective To analysis sputum culture pathogenic bacteria distribution and drug resistance analysis of patients with respiratory tract infection in the Cardio-cerebrovascular Sisease Hospital 2009 -2012 for clinical anti-irdection treatment. Methods Made clinical specimens by aerobic and facultative anaerobic cultivation; Drug sensitive adopted K-B law;Methicil- lin resistant staphylococcus aureus(MRSA), extend spectrum lactamase (ESBL) adopts the ministry of health inspection confirmation procedures. Results From 2009 to 2012,trained patients specimens,5 835 strains, cultivated a positive speci- mens of 2 375 strains and the positive detection rate was 40.70%. Escherichia coli ,Staphylococcus aureus ,Coagulase nega- tive staphylococcus aureus , Klebsiella pneumoniae , Pseudomonas aeruginosa , and Stenotrophomonas maltophilia for the main pathogenic bacteria. Staphylococcus aureus was highly resistant to penicillin, vancomycin and their stead lannings sensi- tive;E, coli and klebsiella pneumoniae to cefuroxime,had high resistance to ciprofloxacin,the imine south, piperacillin/he ba- tan,cefoperazone/shu batan had high sensitivity;Pseudomonas aeruginosa to gentamiein,had high resistance to piperaciliin, of piperacillin/he batan,ciprofloxacin,levofloxacin has a high sensitivity. Conclusion Bacterial resistance was more serious, and should pay more.
作者 张艳 权志博
出处 《现代检验医学杂志》 CAS 2013年第6期148-150,153,共4页 Journal of Modern Laboratory Medicine
基金 陕西省特色专业医学检验基金项目(编号:2010-13-47).
关键词 心脑血管病 病原菌分布 耐甲氧西林金黄色葡萄球菌 耐药分析 eardio-cerebrovascular disease pathogenic bacteria distribution MRSA resistance analysis
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