上海市青浦区2012年疑似预防接种异常反应监测分析

Surveillance on suspected adverse events following immunization in Qingpu district of Shanghai city in 2012

目的分析青浦区2012年疑似预防接种异常反应（AEFI）的发生情况，评价AEFI监测系统运行状况及预防接种安全性。方法采用描述性流行病学方法对2012年青浦区AEFI监测资料进行分析。结果青浦区2012年共报告AEFI586例，报告发生率为136．56例／10万剂，其中一般反应581例（99．15％），异常反应4例（0．68％），偶合征1例（0．17％）；较多分布在5～8月（49．66％）；主要为发热（50．34）和局部红肿（33．96％）；报告发生数较多的产品有白百破、流脑A群、流感菌（HIB）；报告发生率居前3位的产品是：五联、白百破、流脑A群。586例AEFI中，治愈584例，好转2例。结论青浦区AEF!监测敏感性较高，但仍需要加强AEFI监测工作，应进一步强化预防接种规范操作，注重公众沟通。

Objective To analyze the occurrence of suspected adverse events following immunization （AEFI） in Qingpu district, and to evaluate the operation of AEFI surveillance system and the safety of vaccination. Methods Descriptive epidemiology was adopted to analyze AEFI data in Qingpu district in 2012. Results A total of 586 AEFI cases were re- ported, with an incidence of 136.56/103, including 581 eases with common reactions（99.15% ）, 4 cases with abnormal reactions（0.68% ）, 1 case with coincidental events （0.17%）. AEFI cases tended to occur from May to August （49. 66% ） , mainly including fever （ 50.34% ） and local swelling （ 33.96% ）. AEFI cases were likely to occur after the injec- tion of DPT vaccine, MenV - A vaccine and hemophilus influenza type B （HIB） vaccine, and the top three were Pcnta - components vaccine, DPT vaccine, MenV - A vaccine. Of the 586 reported cases, 594 were cured, 2 improved. Conclu- sions AEFI surveillance shows a higher sensitivity in Qingpu district, but needs further improving. Standardized vaccina- tion should be strengthened, as wall as public communication.