人血浆脂蛋白相关磷脂酶A2与脑梗死患者颈动脉斑块稳定性关系

The association between the levels of plasma lipoprotein-associated phosphol-opase and carotid artery plaque

目的:探讨人血浆脂蛋白相关磷脂酶A2与颈动脉斑块的相关性。方法:选择河北医科大学第二医院神经内科发病72小时内的住院急性脑梗死患者72例为病例组和30例该院体检中心非脑梗死者为对照组,病例组行颈动脉彩色多普勒超声检查观察斑块大小形态及回声特点。病例组与对照组均采用双抗体酶联免疫吸附测定法(ELISA)检测其治疗前血浆Lp-PLA2水平,同时检测病例组、对照组患者血浆中CHOL、TG、LDL-C、HDL-C水平。结果:病例组包括不稳定斑块组23例,稳定性斑块组23例,混合斑块组15例,无斑块组11例。病例组患者血浆Lp-PLA2水平高于对照组(P<0.05),差异具有统计学意义;病例组不稳定粥样斑块组血浆Lp-PLA2水平高于稳定性斑块组、混合性斑块组和无斑块组,混合性斑块组血浆LpPLA2水平高于稳定性斑块组和无斑块组,稳定性斑块组血浆Lp-PLA2水平高于无斑块组(P<0.05),差异均具有统计学意义;无斑块组血浆Lp-PLA2水平低于对照组(P>0.05),无统计学差异。结论:血浆Lp-PLA2水平可能是预测脑梗死患者颈动脉不稳定斑块的一个生物学标志物。

Objective： To detect the association between the levels of plasma lipoprotein-associated phospholipase A2 （Lp- PLA2） and carotid artery plaque. Methods： Selected 72 cases of cerebral infarction in patients as the case group and 30 eases of healthy subjects as control group, and the case group were accepted carotid artery color doppler ultrasound. The plasma Lp-PLA2 level were detected by double antibody enzyme linked immunosorbent assay （ELISA） in case group and control group, while the plasma CHOL, TG, LDL-C, HDL-C level were detected at the some time. Results ： The case group included 23 were unstable plaque group, 23 were stable plaque group, 15 with mixed plaques and 11 were no plaque group, the plasma Lp-PLA2 levels of tile case group were higher than the control group, and the difference was statistical significance （ P 〈 0. 05 ）. The plasma Lp-PLA2 levels of the unstable atheromatous plaque group are higher than any other groups; the plasma Lp-PLA2 levels of the mixed plaques group were higher than the stable plaque and no plaque group ; the plasma Lp-PLA2 levels of the stable plaque group were higher than no plaque group ; all of the differences had statistical significance（ P 〈 0.05 ）. Conclusion： Plasma Lp-PLA2 levels could be a predicted biological marker of unstable carotid plaques.