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雌、孕激素受体和基质金属蛋白酶-2在子宫腺肌症中的表达及意义 被引量：6

EXPRESSION AND SIGNIFICANCE OF ER,PR AND MMP-2 IN UTERINE ADENOMYOSIS
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摘要 目的探讨雌激素受体(ER)、孕激素受体(PR)及基质金属蛋白酶-2(MMP-2)在子宫腺肌病(UAM)中的表达和意义。方法应用免疫组化二步法检测35例UAM患者的异位内膜、在位内膜及38例非UAM患者正常内膜中ER、PR和MMP-2的表达情况,通过统计学方法行对照研究。结果 (1)UAM异位内膜组织中ER、PR的表达较对照正常内膜低(P<0.05);(2)UAM异位内膜中MMP-2表达水平显著高于正常内膜组(P<0.01);(3)MMP-2蛋白在UAM异位内膜中表达有周期性变化,增生期高于分泌期(P<0.05),而在在位内膜及对照内膜中表达无明显周期性变化。结论 ER表达并非子宫腺肌病的主要致病因素;MMP-2在异位内膜的高表达可能使异位内膜具有更高的侵袭性,并且在增生期表达活跃。 Objective To explore the expression and significance of ER, PR and MMP - 2 in Uterine Adenomy- osis （UAM）. Methods Immunohistochemical method was employed to detect the expression of estrogen（ER） ,pro- gesterone receptor（PR） and Matrix Mealloproteinase- 2（ MMP-2） in the ectopic endometrium and the eutopic en- dometrium of 35 patients with UAM and the normal controls（ n = 38 ） ,then the correlation of the expression of them was analyzed. Results （ 1 ） The expression of ER and PR in ectopic endometrium were significantly lower than that in normal endometrium （ P 〈 O. 05 ） ; （2） The expression of MMP - 2 was obviously higher in the ectopic endometri- um of UAM patients than that of controls（ P 〈0. O1 ） ;（3 ）The expression of MMP-2 protein in ectopic endometri- um showed cyclic change obviously, the expression level of MMP -2 in proliferate stage was significantly higher than that in protestation stage （P 〈 0.05 ）. But in eutopic endometrium and the normal controls showed no cyclic change. Conclusions The high expression of MMP - 2 in the ectopic endometrium suggests that the ectopic endome- trium with UAM may be more invasive and the expression was higher in proliferation stage.
作者 郭桂兰 沙仁高娃 鲁秀英 甘芳 张玉芳
机构地区 青海大学附属医院妇科
出处 《青海医学院学报》 CAS 2013年第4期274-277,共4页 Journal of Qinghai Medical College
关键词 子宫腺肌病 基质金属蛋白酶-2 雌激素受体 孕激素受体 UAM MMP-2 ER PR
分类号 R71 [医药卫生—妇产科学]
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参考文献12

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二级参考文献28

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共引文献18

同被引文献110

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引证文献6

二级引证文献33

青海医学院学报
2013年 第4期

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