血清S-CD105在结直肠癌中的表达及临床意义

Expression and Clinical Significance of Serous S-CD105 in Colorectal Cancer

目的探讨血清S-CD105在结直肠癌中的表达及临床意义。方法选择北京军区天津疗养院收治的经病理证实的结直肠癌35例（结直肠癌组）、结直肠息肉10例（结直肠息肉组）和健康体检者10例（对照组）,用酶联免疫吸附法（enzyme-linked immunosorbent assay,ELISA）检测血清S-CD105的浓度,观察其与临床病理指标的关系及预后。结果结直肠癌组术前S-CD105浓度均高于术后及结直肠息肉组、对照组（P〈0.05）;结直肠息肉组和对照组比较差异无统计学意义（P〉0.05）;结直肠癌组术后S-CD105浓度均低于结直肠息肉组和对照组,但差异无统计学意义（P〉0.05）。血清S-CD105浓度随着淋巴结转移、Dukes分期升高及癌组织中血管内皮生长因子（VEGF）表达增强而明显升高（P〈0.05）;术后1~3年发生远处转移的5例结直肠癌血清S-CD105浓度明显升高。结论血清SCD105表达对评价结直肠癌的预后和监测复发、转移具有重要的临床价值。

Objective To explore the expression and clinical significance of serous S-CD105 in colorectal cancer. Methods Concentrations of serous S-CD105 in 35 patients with colorectal cancer confirmed by pathology（ group A）,10 patients with colorectal polyp（ group B） and 10 persons by health examinations（ control group） in our hospital were detected by using enzyme-linked immunosorbent assay（ ELISA）,and the relationships between concentrations with clinical factors and prognosis were also observed. Results The preoperative concentration of serous S-CD105 in group A was significantly higher than those in group A after operation,group B and control group（ P ＆lt; 0. 01,P ＆lt; 0. 05）; the difference between group B and control group was not statistically significant（ P ＆gt; 0. 05）; the postoperative concentration of serous S-CD105 in group A was lower than those of group B and control group,but the differences were not statistically significant（ P ＆gt; 0. 05）. The concentration of serous S-CD105 obviously was elevated with the lymph node metastasis,the later stage of Dukes and the enhanced expression of vascular endothelial growth factor（ VEGF） in the cancer tissue（ P ＆lt; 0. 05）; concentrations of serous S-CD105 obviously raised in 5 patients with colorectal cancer and with distant metastasis postoperative 1-3 years. Conclusion The expression of serous S-CD105 in colorectal cancer has important clinical significance in evaluating the prognosis,monitoring recurrence and metastasis of colorectal cancer.