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先天性心脏病术后肝素诱导性血小板减少症一例并文献复习 被引量：7

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摘要 肝素诱导血小板减少症（heparin-induced thrombocytopenia,HIT）是使用肝素治疗的副作用之一。血小板因子4与肝素形成复合物时,常由IgG型抗体介导并引起血小板活化,最终激活凝血系统,促使大量凝血酶生成,机体处于高凝状态,实际上HIT是一类促血栓形成疾病[1]。然而,
作者 范庆坤 杨军 张李涛 赵耿生 张真路 熊青峰
机构地区 亚洲心脏病医院检验中心 亚洲心脏病医院影像中心
出处 《解放军医药杂志》 CAS 2013年第12期114-116,共3页 Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词 血小板因子4 肝素 血小板减少
分类号 R973.2 [医药卫生—药品]
  • 相关文献

参考文献7

  • 1Kelton J G,Arnold D M,Bates S M. Nonheparin anticoagulants for heparin-induced thrombocytopenia[J].{H}The New England Journal of Medicine,2013,(08):737-744.
  • 2Watson H,Davidson S,Keeling D. Guidelines on the diagnosis and management of heparin-induced thrombocytopenia:Second edition[J].{H}British Journal of Haematology,2012,(05):528-540.
  • 3Linkins L A,Dans A L,Moores L K. Treatment and prevention of heparin-induced thrombocytopenia:Antithrombotic therapy and prevention of thrombosis,9th ed:American college of chest physicians evidence-based clinical practice guidelines[J].{H}CHEST,2012,(2 Suppl):495S-530S.
  • 4Greinacher A,Selleng K. Thrombocytopenia in the intensive care unit patient[J].Hematology the Education Program of the American Society of Hematology American Society of Hematology Education Program,2010,(04):135-143.
  • 5安育林,周更须,王辉,刘宇航.先天性心脏病术后出血原因的分析及处理[J].中国循证心血管医学杂志,2013,5(3):270-271. 被引量：5
  • 6Hess C N,Becker R C,Alexander J H. Antithrombotic therapy in heparin-induced thrombocytopenia:Guidelines translated for the clinician[J].{H}Journal of Thrombosis and Thrombolysis,2012,(04):552-561.
  • 7Warkentin T E,Sheppard J I,Moore J C. Quantitative interpretation of optical density measurements using pf4-dependent enzyme-immunoassays[J].{H}Journal of Thrombosis and Haemostasis,2008,(08):1304-1312.

二级参考文献7

共引文献4

同被引文献101

  • 1张庆祥,李宗虓,李秀勇,靖文斌.心脏术后肝素诱导血小板减少二例[J].中国心血管病研究,2009,7(10):766-767. 被引量：1
  • 2熊华杰,况晶茹,胡迎宾.伊立替康联合顺铂和5-FU治疗晚期胃癌[J].江西医学院学报,2006,46(3):102-103. 被引量：1
  • 3Kehon JG,Warkentin TE. Heparin-induced thrombocytopenia:A his- torical perspective [ J ]. Blood, 2008,112 ( 7 ) : 2607-2616.
  • 4Watson H, Davidsou S, Keeling D, et al. Guidelines on the diagnosis and management of heparin-induced thrombocytopenia : Second edition [ J]. British journal of haematology,2012,159(5 ) :528-540.
  • 5Kelton JG, Arnold DM, Bates SM. Nonheparin anticoagulants for hepa- rin-induced thrombocytopenia[ J]. The New England journal of medi- cine,2013,368 (8) :737-744.
  • 6Lo GK, Juhl D, Warkentin TE, etal. Evaluation of pretest clinical score (4 tg) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings[ J]. Journal of thrombosis and haemostasis : JTH, 2006,4(4) :759-765.
  • 7Warkentin TE,Levine MN,Hirsh J,et al.Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin[J].N Eng J Med,1995,332(20):1330-1335.
  • 8Greinacher A,Eichler P,Lubenow N,et al.Heparin-induced thrombocytopenia with thromboembolic complications:Meta-analysis of 2 prospective trials to assess the value of parenteral treatment with lepirudin and its therapeutic aPTT range[J].Blood,2000,96 (3):846-851.
  • 9Reilly MP,Taylor SM,Hartman NK,et al.Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA[J].Blood,2001,98 (8):2442-2447.
  • 10Bhatt VR,Aryal MR,Shrestha R,et al.Fondaparinux-associated heparin-induced thrombocytopenia[J].Eur J Haematol,2013,91 (5):437-441.

引证文献7

二级引证文献28

解放军医药杂志
2013年 第12期

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