帕金森病患者视觉功能障碍的研究

RESEARCH OF VISUAL DYSFUNCTION IN PARKINSON'S DISEASE

目的:探讨帕金森病患者视觉认知功能的变化。方法:选择从2008.01到2013.01期间在昆明医科大学第一附属医院神经内科就诊的H-Y分期为1或2期的帕金森病患者120例,男性76例,女性44例。和同期在我院进行健康检查的健康对照组100名,男性60例,女性40例。对所有患者进行MoCA、汉密顿抑郁和焦虑量表评价,所有受试者均不存在痴呆(MoCA≥26分),亦不处于焦虑、抑郁状态(HAMA≤14分,HAMD-17项≤16分),并进行班德视觉完形测验(Bender Visual Gestalt Test)和视觉诱发电位(VEP)检测。结果:PD组VEP的P100潜伏期(115±11)较健康对照组(103±9)ms明显延长(P<0.01),P100波幅(6.3±3.0)较健康对照组(7.7±2.6)μV增宽(P<0.05)。班德视觉完形测验PD组患者全球评分系统(Global Scoring System GSS)得分明显低于健康对照组,差异有统计学意义。结论:帕金森病患者在发病早期即存在不同程度的视觉功能障碍,对于此类患者,我们应该早期给予训练和指导,从而减缓患者认知功能障碍的发展和避免跌倒发作,提高患者的生活质量。

Objective：To research the visual cognitive function in patients with Parkinson＇s disease. Methods：Select 2008.01-2013.01 first affiliated hospital of Kunming medical university department of neurology,120 cases of outpatient and inpatient as Parkinson＇s disease group（Hoehn-Yahr stag 1 or 2）and 100 healthy controls who matched for age,sex and education were used as controls. All subjects were not dementia（score ≥ 26 on MoCA）or anxiety（score ≤ 14 on HAMA）or depresse（score ≤ 16 on HAMD-17）. All of the subjects were take Bender Visual Gestalt Test and VEP. Results：In the observation group,the P100 latency（115±11） than in healthy control group（103±9） ms was significantly longer（P0.01）,P100 amplitude（6.3±3.0） than the healthy control group（7.7±2.6）μV widened（P0.05）.The score of GSS PD is lower than healthy control group（P 0.01）.Conclusion： The study showed that in the early, the ability of the visualcognitive function in patienis with PD is impaired. For such patients,they should be given early training and guidance to improve the patient＇s quality of life.