益气补肾化瘀通络中药对原发性肾病综合征激素维持治疗阶段的治疗作用研究

Investigation of the therapeutic effects of reinforcing-kidney and stasis-dissolving herbs on Primary Nephrotic Syndrome in Hormone Maintenance Stage

目的观察益气补肾化瘀通络中药对原发性肾病综合征(PNS)激素维持治疗阶段的治疗作用。方法将90例PNS在激素维持治疗阶段的患者随机分为2组,对照组45例予单纯激素治疗,治疗组45例在对照组基础上予益气补肾化瘀通络中药治疗。2组连续治疗6个月,观察治疗效果。结果治疗组总有效率84.62%,对照组58.33%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组;治疗组治疗前后在减轻患者临床症状、减少蛋白尿方面比较差异有统计学意义(P<0.05,P<0.01);治疗组的终点事件发生率低于对照组。结论益气补肾化瘀通络中药联合激素对PNS激素维持治疗阶段的治疗作用明显优于单纯激素治疗。

Objective To observe curative effect of reinforcing - kidney and stasis - dissolving herbs on pri mary nephrotic syndrome in hormone maintenance stage. Methods Ninety patients of primary nephrotic syndrome in hormone maintenance stage were randomized into two groups：forty- five cases in treatment group and forty- five ea ses in control group. Control group received only hormone treatment. Treatment group received reinforcing - kidney and stasis - dissolving herbs on the basis of hormone treatment. Efficacy of treatment was studied after six months of treat ment. Results The total effective rate of treatment group was 84.62%, obviously higher than 58.33% of control group（ P 〈 0.05 ）. In treatment group, the clinical symptoms and 24 hours urinary protein before and after treatment were compared, the difference was significant（ P 〈 0.05 or P 〈 0.01 ）. The endpoint events rate in treatment group was lower than that in control group. Conclusion The curative effect of reinforcing - kidney and stasis - dissolving herbs on primary nephrotic syndrome in hormone maintenance stage was obviously better than the treatment of simple hor mone.