石斛汤联合促排卵药治疗多囊卵巢综合征不孕症的临床观察

Clinical observation of Shidou decoction combined with ovulation stimulator on infertility with polycystic ovarian syndrome

目的观察石斛汤联合促排卵药克罗米芬(CC)、尿促性素(HMG)治疗多囊卵巢综合征(PCOS)不孕症的临床疗效。方法将120例PCOS患者随机分为4组。治疗组2组,分别运用石斛汤联合CC、HMG治疗PCOS不孕症各30例;对照组2组,分别单纯运用CC、HMG治疗各30例。观察每组排卵例数、妊娠例数、每周期用药总量、B超监测排卵前卵泡大小、卵泡最大直径与最小直径的差值、排卵前子宫内膜厚度。结果治疗组与对照组排卵例数、排卵前卵泡大小相近,比较差异无统计学意义(P>0.05);治疗组受孕例数、排卵前子宫内膜厚度均高于对照组,卵泡最大直径与最小直径差值、周期用药量少于对照组(P<0.05)。结论石斛汤可减少促排卵药物的应用,促进卵泡生长、变圆,促进子宫内膜增长,提高妊娠率,对PCOS不孕症有较好临床疗效。

Objective To observe the effect of Shidou decoction combined with ovulation stimulator（clomi phene citrate（CC）, human menopausal gonaclotxopin （HMG）） on infertility with polycystic ovarian syndrome （P COS）. Methods 120 PCOS patients were randomly divided into four groups, treatment group A （combination of Shidou decoction and CC） ,treatment group B （combination of Shidou decoction and HMG）, control A（CC） and con trol group B（HMG）. After treatment, number of ovulation, pregnancy, the total amount of medication in a course and the B - monitoring ovulation follicle size, the difference between the maximum diameter and the minimum diameter of follicles, and endometrial thickness in each group were observed. Results There was no significant difference be tween control group and treatment group on number of ovulation and ovulation follicle size （ P 〉 0.05 ）. Cases of preg nancy and endometrial thickness in treatment group were higher than those in control group （ P 〈 0.05 ）. The difference between the maximum diameter and the minimum diameter of follicles and the total amount of medication in a course in treatment group were lower than those in control group （ P 〈 O. 05 ）. Conclusion Shidou decoction can decrease use of ovulation stimulator, promote the development and rounding of follicle and endometrium growth. Shidou decoc tion has better effect on PCOS.