妊娠滋养细胞肿瘤与病毒关系的研究

STUDIES ON RELATIONSHIP BETWEEN PREGNANCY TROPHOBLASTIC TUMORS AND VIRUS

目的 :研究滋养细胞肿瘤与病毒的关系。方法 :采用聚合酶链式反应 (PCR)对 82例滋养细胞肿瘤中的 HPV、HCMV进行了筛检 ,并配以超微结构对比观察。结果 :PCR检测发现 :30例正常胎盘绒毛中 ,HPV全部阴性 ;82例滋养细胞肿瘤中仅有 1例阳性。二者检出率无统计学差异。在 2 7例滋养细胞肿瘤中检测 HCMV,结果全部阴性。电镜观察发现 :滋养细胞肿瘤的一系列超微病变提示病毒感染迹象。结论 :正常胎盘绒毛中无 HPV感染 ,滋养细胞肿瘤的发生与 HP 、HVMV感染均无关。但根据超微形态学研究 。

Object:To determine the relationship between trophoblastic tumors and virus.Methods:Human papillomavirus(HPV)and human cytomegalovirus(HCMV) were detected with polymerase chain reaction(PCR) in 82 cases of trophoblastic tumor,Corresponding ultrastructural changes was studied with electron microscopy(EM).Results:NO HPVDNA was detected in 30 cases of normal placentas with PCR method,while among the 82 cases of trophablastic tumors,only 1 case was HPVDNA positive.There was no significant difference between these two groups.HCMV was studied in 27cases of trophablastic tumor but all of the cases were negative.Yet ultrastructurally,a series of changes likely suggested that virus infection could be found in trophoblastic tumor cells.Conclusion:Though HPV and HCMV were rarely found in trophoblastic tumors by PCR method,the possibility of other virus existence could not be excluded on the base of EM observation.