多项血清肿瘤标志物联合检测对原发性肝癌的诊断价值

CLINICAL EVALUATION OF COMBINED DETECTION OF SEVERAL SERUM TUMOR MARKERS IN THE DIAGNOSIS OF PRIMARY HEPATIC CARCINOMA

目的 :探讨血清甲胎蛋白 (AFP)、唾液酸 (SA )、α- L -岩藻糖苷酶 (AFU )及转化生长因子β1 (TGF-β1 )各项标志物在肝病患者中对 PHC的诊断价值及联合检测的意义。方法 :对 2 2 6例肝病患者血清中各项标志物的水平进行检测并对阳性率进行计算。结果 :各种标志物诊断 PHC的敏感性为 AFU(93.2 % ) >TGF- β1 (80 .0 % ) >AFP(72 .9% ) >SA(6 7.8% ) ,特异性为 SA(94.6 % ) >AFP(83.8% ) >TGF- β1 (82 .0 % ) >AFU(79.0 % ) ,联合 4项检测可将阳性率提高到 96 .6 %。结论 :多项肿瘤标志物联合检测对 PHC尤其是 AFP阴性

Objective:To evaluate the practical significance of alphafetoprotein(AFP),sialic alid (SA),alpha L fucosidase(AFU) and transforming growth factor β 1(TGF β 1) in the diagnosis of primary hepatic cancer (PHC).Methods:Four serum tumor markers were determined in 167 cases with various types of hepatitis,and 59 with PHC.Results:According to statistics,the diagnostic sensitivity of these markers in PHC were AFU(93.2%)>TGF β 1(80.0%)>AFP(72.9%)>SA(67.8%),respectively,and the specificity were SA(94.6%)>AFP(83.8%)>TGF β 1(82.0%)>AFU(79.0%).Simultaneous detection of these markers gave a diagnostic sensitivity in PHC of 96.6%.Conclusion:The combined assay of serum tumor markers is valuable in the diagnosis of PHC,especially in AFP negative patients.