恶性肿瘤患者血浆凝血因子Ⅶ与血液粘滞度变化的初步临床研究

INITIAL CLINICAL RESEARCH FOR THE CHANGE OF PLASMA COAGULATE FⅦ AND BLOOD VISCOSITY IN MALIGNANT TUMOR PATIENT

目的 :研究凝血因子 (F )和血液粘滞度对恶性肿瘤的影响。方法 :检测肿瘤患者 F 和血液流变学指标 ,其中 F :Ag采用 EL ISA法 ,F :c采用经典一期法 ,F a采用重组可溶性组织因子 (r STF)一期法测定。结果 :肿瘤组 F :Ag、F a、血浆粘度 (η p)、ESR、Fib较对照组显著升高 ;复发转移组 F a全血低切粘度 (ηL )、η p、ESR、Fib较未复发转移组显著升高。结论 :恶性肿瘤血液呈高粘滞型高凝状态 ,F a和

Objective:To study the effect of plasma coagulate FⅦ and blood viscosity on malignant tumor.Methods:To detect the indexes of FⅦ and blood rheology of tumor patient, for which that FⅦ: Ag was used for enzyme linked immunity(ELISA), FⅦ:c was used for classic phase 1, and FⅦ:a for recombinant soluble tissue factor(rSTF) phase 1.Results:(1)FⅦ:Ag, FⅦ:a, plasma viscosity(η p), ESR and Fib of tumor group had a significant increase compared with the contrast group;(2) FⅦ:a, blood low rate of shear viscosity(η L), η p, ESR and Fib of tumor group that recurred and metastasized had a significant rise compared with the group that neither recurred nor metastasized.Conclusion:The blood of malignant rumor is in a state of hyperviscosity and hypercoagulability, FⅦ:a and Fib are dangerous factors that lead tumor to metastasize.