我院新生儿科胎膜早破患儿预防感染应用抗菌药物分析

Utilization of Antibacterials for Infection Prevention in Neonate with Premature Rupture of Memberane in Neonatology Department of Our Hospital

目的：了解我院胎膜早破患儿预防感染用抗茵药物情况，为临床合理用药提供依据，探索更好的新生儿预防感染管理模式。方法：调查统计我院2011年7月一2012年12月新生儿科399例胎膜早破患儿预防感染用抗茵药物情况，分析预防用药指征、品种、疗程、不合理用药与后续治疗用药。结果：399例胎膜早破患儿预防感染中，预防用药指标为破膜时间≥18h；抗茵药物品种共4种，其中美罗培南作为预防感染用药不合理；预防用药疗程3～7d，阿洛西林预防感染的病例中，对体质量〉2000g的患儿，疗程3d和5d没有区别，建议新生儿科预防感染用抗茵药物3d，结合血常规、C-反应蛋白（CRP）等复检结果决定是否停用抗茵药物。结论：我院在胎膜早破患儿预防感染用抗茵药物时存在一定不合理用药情况，须加强规范化管理。

OBJECTIVE： To investigate the use of the antibacterials for infection prevention in neonate with premature rupture of memberane in our hospital, and to provide evidence for clinical rational drug use and explore better neonatal infection prevention management mode. METHODS： The use of the antibacterials for infection prevention in 399 neonates with premature rupture of memberane from Jul. 2011 to Dec, 2012 in our hospital were analyzed statistically, including prophylactic indication, varieties, course of treatment, irrational medication, succedent medication. RESULTS： Among infection prevention for 399 neonates with premature rupture of membranes, preventive medication index was film rupture time≥18 h; a total of 4 kinds of antibacterial were used, it was unreasonable to choose meropenem for infection prevention. The preventive medication lasted for 3-7 d. Among medical cases of azlocillin prevent infection, there was no difference among children with body weight 〉2 000 g after 3 d or 5 d of treatment. It is suggested that the blood routine and CRP results were reviewed to decide whether to stop antibiotics after 3 d of tretatment. CONCLUSIONS： The use of antibacterials for infection prevention in neonate with premature rupture of memberane is somewhat irrational in our hospitial, and the standard management must be strengthened.