支气管哮喘和慢性阻塞性肺疾病重叠的治疗策略

Therapeutic strategy of the overlap syndrome of bronchial asthma and chonic obstructive pulmonary disease

支气管哮喘（简称哮喘）和COPD两者的定义都表现为气流受限，但它们的危险因素及临床表现有所不同。然而，大量的临床观察发现哮喘患者表现出COPD表型，反过来，在COPD患者中也存在哮喘表型。流行病学资料表明老年慢性阻塞性气道疾病的患者中，一半或以上患者中存在哮喘和COPD重叠的现象，而这部分人被排除在目前各种临床药物试验之外。因此，对哮喘和COPD重替的研究有助于更好地解决哮喘COPD重叠患者的“特殊”临床特点，同时为COPD发病机制提供新的观点，亦为更好地预防、治疗及管理该重叠综合征作出最佳的选择。

The risk factors and clinical manifestations between bronchial asthma （asthma） and chronic obstructive pulmonary disease （COPD） are different, ahhough both of them are airflow obstruction in definition. However, a large number of clinical observations show patients with asthma present with COPD phenotype,in turn. patients with COPD also coexist with asthma phcnotype. The cpidemiological data show that half or more of old patients with COPD exist asthma COPD overlap phenomenon, while those patients are excluded from clinical trials of ＂ pure＂ asthma or COPD. Therefore, the study of overlap syndrome between asthma and COPD helps to resolve the ＂special＂ clinical characteristics for those patients and provides a new perspective for the pathogenesis of COPD,it also makes better choice for the prevention, treatment and management of the overlap.