首参颗粒对颈动脉粥样硬化患者血脂及炎症因子的影响

Effect of Shoushen Granules on Level of Blood Lipids and Inflammatory Cytokines When Treating Carotid Artherosclerosis

目的:观察首参颗粒对颈动脉粥样硬化患者外周血总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及炎症因子C反应蛋白(CRP)、白细胞介素6(IL-6)的影响。方法:156例颈动脉粥样硬化患者随机分为中药组83例和西药组73例。中药组服用首参颗粒,西药组口服普法他汀片,疗程均为6个月。于治疗前、治疗后3、6个月分别观察血脂及CRP、IL-6的变化。结果:中药组治疗后TG、TC/HDL-C比值较治疗前均下降明显(P<0.05或P<0.01),HDL-C值上升明显(P<0.01),与西药组同期比较差异无统计学意义(P>0.05);中药组治疗后CRP、IL-6表达较治疗前均明显下降(P<0.01),与西药组同期比较差异无统计学意义(P>0.05)。结论:首参颗粒可改善颈动脉粥样硬化患者脂质代谢紊乱,降低CRP、IL-6水平进而有效干预治疗颈动脉粥样硬化病变。

Objective：To study the effect of Shoushen Granule on the levels of blood lipids, including total cholesterol （ TC）, triglyeride （TG） , high - density lipoprotein cholesterol （ HI）L - C）, low - density lipoprotein cholesterol （ LDL - C） and irrflammatory cytokines including C Reactive Protein （CRP） and Interleukin 6 （IL -6） when treating carotid artherosclerosis. Methods ：Totally 156 cases of carotid artherosclerosis were randomized into the Chinese medication group （83 cases） and Western medication group （73 cases）. The Chinese medication group was given Shoushen Granules and the Western group was given pravastatin sodium tablets. The course of treatment was six months. Changes of blood lipids, CRP and IL- 6 levels were observed respectively. Results：After six moths, the levels of TG, CRP and IL- 6 and ratio of TC/HDL - C were lower in the Chinese medication group compared with those before treatment （ P 〈 0.01 ）, while the levels of HDL - C were significantly increased after treatment （ P 〈 0. O1 ） and had no statistical difference compared with Western medication group at the same period （ P 〉 O. 05 ）. Conclusion ： Shoushen Granules maybe interfere carotid arth- erosclerosis pathological changes by adjusting disorder of lipid metabolism and reducing the expression levels of CRP and 1L - 6.