TORCH感染治疗与否对胎婴儿预后的关系探讨

Study on the fetal progonosis after treatment of the pregnant women with TORCH infection.

目的 :探讨TORCH感染治疗与否与胎婴儿预后的关系。方法 :用ELISA结合PCR方法对妊娠 6周 2 0周间检出TORCH感染而不愿终止妊娠的 95例孕妇进行治疗后 ,随访直至分娩 ,与同期检出TORCH感染而未行治疗的 195例中晚期孕妇比较。结果 :在妊娠各期TORCH感染情况大致相同 ,只是各种病原体比例有所差异。继往有感染者 ,孕期易复发性感染。研究表明 :无论在妊娠哪一期感染 ,均可以发生母婴垂直传播 ,治疗后并不能减少母婴垂直传播率 ,对早孕TORCH感染者 ,虽经积极治疗 ,除了可改善部分围产儿感染、出血等并发症外 ,尚不能从根本上纠正出生缺陷及胎婴儿的发育落后。结论 :在早孕期间检出TORCH活动性感染者 ,可考虑胎儿的健康建议终止妊娠。

Objectives:To study the relationship of the prognoses of fetus and infants whether the pregnant women affected by TORCH pathogen were treated or not .Methods:Two groups of pregnant women were detected to be TORCH infection using enzyme linked immunosorbent assay(ELISA) technique combined with polymerase chain reaction(PCR).The study group :95 cases(6～20 gestational weeks )of the pregnant women who were infected with TORCH pathogen and not reluctant to be aborted were treated as soon as they were diagnosed .The control group:195 cases with TORCH infection from the second trimester to the third trimester were not treated.Both groups were followed up to delivery. Results:The rates of TORCH infection of pregnant women in two groups were similar in gereral no matter in which trimester the infection was,the maternal-fetal transmission could occur.The treatment could nou decrease the rate of the maternal-fetal transmission.Even though the infected women in the first trimester were treated without delay,the birth defects and the fetal retardation could not improved foundamentally,and only the complications such as perinatal infection and bleeding could partially improved.Conclusions:when pregnant women were found to be actively infected with TORCH pathogen in the first trimester,the pregnancy should be ended timely in case the unnecessany psychological and economical burden could be brought to the society and the family.