摘要
传统的预测方法在构造特征向量时只考虑了氨基酸的组成,而自相关系数不仅能够很好地反映序列中氨基酸的位置信息,而且考虑了序列内部不同位置的氨基酸间的相互影响。设计了一种将氨基酸组成和自相关系数相结合的方法来构造特征向量;在Chou提出的伪氨基酸组成模型(pseudo-amino acid composition,PseAAC)的基础上,通过扩展信息重新构造了伪氨基酸组成模型,并将其与自相关系数组合在一起来构造特征向量。分别使用两种方法编码,选用支持向量机作为预测工具,在数据集Z277、Z498以及独立测试集D138上进行了若干实验,对比结果显示,新方法比传统的氨基酸组成方法的准确率分别平均提高了7.43%和8.53%,证明了新方法是有效的。
In the traditional prediction methods, only the composition of amino acids was taken into account in con- strutting feature vector. While both the position and interaction of the amino acids which are at the different loca- tions can be reflected well by the correlation coefficient. Firstly, this paper designs a method which combines amino acid composition and correlation coefficient. Secondly, on the basis of the pseudo-amino acid composition (PseAAC) model proposed by Chou, this paper reconstructs the PseAAC model by extending the information, and combines the PseAAC model and autocorrelation coefficient to construct feature vector. Using the two new methods for coding, several experiments are conducted on the datasets Z277, Z498 and the independent test sets D138 with the prediction tool of support vector machine. The experimental comparison results show that the accuracy of the new method can improve 7.43% and 8.53% on average than the traditional amino acid composition method, which proves that the new method is more effective.
出处
《计算机科学与探索》
CSCD
2014年第1期103-110,共8页
Journal of Frontiers of Computer Science and Technology
基金
国家自然科学基金Nos.61073117
61175046
61203290
安徽大学博士科研启动经费No.33190078~~