28例庚型肝炎流行病学及临床分析

Epidemiology and Clinical Analysis of 28 Patients with Hepatitis G

目的:调查庚型肝炎的流行病学及临床特点。方法:28例患者系我院住院病人,男16例,女12例,年龄23～69岁,其中急性肝炎8例,慢性肝炎轻度4例,慢性肝炎中度4例,慢性重型肝炎3例,活动性肝硬变9例;检测患者HGV-RNA采用RT-PCR法。结果:28例患者中有输血史者15例(53.6%),有静脉注射毒品史者1例(3.6%),不明原因者12例(42.6%);临床症状以纳差(100%),乏力(92.9%),尿色加深(75%)及恶心(53.6%)为主;病毒标志物检洲单纯庚型肝炎病毒感染4例(14.3%),乙、庚重叠感染13例(46.4%),丙、庚重叠感染6例(21.4%),乙、丙、庚重叠感染3例(10.7%);肝功能检测:TBil:45.08±22.48μmol/L,ALT 318.64±359.95U/L;纤维化指标:HA 515.39±800.79μg/L,LN 323±578.13μg/L,PCⅢ151.71±47.34μg/L,C Ⅳ 67.35±15.27ng//L。结论:①HGV主要经输血途径传播。同时存在其他肠道外途径传播如静脉注射毒品等。②HGV可引起急性、慢性、重型肝炎、肝硬变,易复发,易致慢性化。③HGV可与HGV和/或HCV同时或重叠感染。④HGV一般临床症状及肝功能损害较轻。

Aim:This study was aimed at investigating the epidemiologic and clinical characteristics. Methods:28 cases wsa hospitalized in our hospital of the 28 patients 16 were male and 12 female, aged 23--69 years. Of them, 8 were acute hepatitis, 4 were mild (CH), 4 moderate (CH), 3 chronic severe hepatitis, 9 active hepatocirrhosis. HGV RNA was detected by RT-PCR. Result; 15 patients had received blood or plasma transfusion (53. 6%), 1 was an intravenous drug abuser (3. 6% ). The other 12 had no direct cause (42. 6% ). The main clinical manifestation was loss of appetite (100%), fatigue (92. 9%), greenish -brown colour urine (75% ) , nausea (53. 6%). Virus marks tests showed 4patients were infected HGV only. 13 HBV coinfection HGV, 6 HCV coinfection HGV, 3 HCV, HBV, HGV coinfection. Sera tests of hepato-function showed: TBil 45. 08±22.48μmol/L, ALT 318. 64±359. 95U/L Sera tests of fibrosis marks showed: HA 515. 39±800. 79μg/L,LN 323±578. 13μg/L,PCⅡ151. 71±47. 34μ/L,CLIV 67. 35±15. 27ng/L. Conclusion: ①HGV infections is a parenteral transmission route of viruses (blood transfusion) . ② HGV infection can cause a-cute hepatitis and develop a chronic course. ③ HGV infection occurs frequently in coinfection with HBV or/and HCV. ④ Hepatitis G seems to have a mild course as ALT values are concerned.