自发性细菌性腹膜炎患者腹水IL-8测定及临床意义

Clinical Significance of Measurement of IL-8 in Ascites of Spontaneous Bac- terial Peritonitis

目的:探讨肝硬变并自发性细菌性腹膜炎(SBP)病人腹水中白细胞介素8(IL-8)水平的变化和临床意义。方法:采用双抗体夹心ELISA法测定48例肝硬变腹水病人血清和腹水中IL-8的含量。结果:在28例SBP病人血清和腹水中IL-8水平明显高于20例漏出性腹水病人(P<0.01);SBP病人腹水中IL-8的水平随着感染被控制而明显下降(P<0.01)。结论:检测腹水中IL-8的含量有助于SBP的诊断和疗效分析。

Aim: To study the clinical significance of levels of interleukin-8 (IL-8) in ascites of spontaneous bacterial peritonitits (SBP) cases. Methods: IL-8 levels of the serum and ascites in 48 cases patients with ascitic fluid of cirrhosis were detected by ELISA. Results:IL-8 levels of the serum and ascites were higher in SBP ascites of 28 cases than in tran-sudate patients of 20 cases (P<0. 01). IL-8 levels were higher in ascites than in serum. With the control of SBP, the ascites level of IL-8 decreased(7J<0. 01). Conclusion: Measurement of IL-8 in ascites is helpful for physician to diagnose SBP and to observe treatment effects.