p53、CK20表达与膀胱尿路上皮癌分级的关系

Relationship Between Expressions of p53 or CK20 and Pathological Grade of Uroepithelium Carcinoma of Bladder

目的探讨p53、CK20在膀胱尿路上皮癌(BUC)组织中的阳性表达与肿瘤分级的关系。方法采用免疫组化法分别检测118例BUC、21例良性病变组织中p53、CK20的表达,并分析两者与BUC病理分级的关系。结果 BUC组织中的p53阳性率为88.1%,明显高于良性病变组织的61.9%,在高级别BUC组织中的阳性表达率(+++)明显高于低级别BUC(P<0.05);CK20在BUC组织中的阳性表达率为28.8%,明显高于良性病变组织的0.0%,在高级别BUC组织中的阳性表达率(++^+++)明显高于低级别BUC。结论p53、CK20在BUC组织中呈阳性表达,且BUC的分级越高,阳性表达越强。

Objective To investigate the relationship between expressions of p53 or CK20 and pathological grade of uroepithelium carcinoma of bladder （BUC）. Methods The expression levels of p53 and CK20 in the 118 cases of BUC and the 21 cases of benign lesions were detected with immunohistochemical method, and the relationship between expressions of p53 or CK20 and pathological grade of BUC were analyzed. Results The expression rate of p53 in the BUC was higher than that of the benign lesion （ 88. 1% vs 61.9% , P 〈 0. 05 ）, the expression rate （ ＋＋＋ ） of the high grade BUC was higher than that of the low grade BUC （ P 〈 0. 05 ）. The expression rate of CK20 in the BUC was higher than that of the benign lesion （28.8% vs 0.0% ,P 〈0.05） ,the expression rate （ ＋＋ or ＋＋＋ ） of the high grade BUC was higher than that of the low grade BUC （P 〈 0.05）. Conclusion The positive expressions of p53 and CK20 was observed in the BUC tissues ,and their positive expressions are correlated with higher tumor grade of BUC.