醋酸甲地孕酮联合化疗治疗晚期胃癌疗效观察

Effect of Megestrol Acetate on Patients with Advanced Gastric Cancer Treated with Chemotherapy

目的观察醋酸甲地孕酮对接受化疗的晚期胃癌患者生活质量的改善作用。方法 38例晚期胃癌患者分为治疗组和对照组。对照组18例采用常规化疗方法治疗;治疗组20例在化疗基础上加用醋酸甲地孕酮。观察2组患者生活质量改善状况及毒副反应。结果治疗组较对照组生活质量有明显改善(P<0.05);胃肠道反应、骨髓抑制等毒副反应减轻(P<0.05)。结论醋酸甲地孕酮联合化疗能有效改善晚期胃癌患者生活质量,减轻化疗毒副反应。

Objective To observe the effect of megestrol acetate on the quality of life of patients with advanced gastric cancer treated with chemotherapy. Methods Thirty-eight patients with advanced gastric cancer were divided into two groups ： 18 patients of the control group received the chemotherapy alone,20 patients of the treatment group received the chemotherapy plus megestrol acetate. The quality of life and the chemotherapy toxicities were campared of the two groups. Results The quality of life of the patients in the treatment group was better than that of the con- trol group （ P 〈 0.05 ）. The incidence rates of gastrointestinal reaction and bone marrow depression of the patients in the treatment group was lower than those of the control group （ P 〈 0.05 ）. Conclusion Megestrol acetate can improve the quality of life in patients with advanced gastric cancer treated with chemotherapy, and lighten the toxicities.