消癌平注射液联合间断化疗治疗老年晚期非小细胞肺癌

Xiaoaiping Injection Combined with Intermittent Chemotherapy for Elderly Patients with Advanced Non-small Cell Lung Cancer

目的观察消癌平注射液联合间断化疗治疗老年晚期非小细胞肺癌患者的疗效及毒副反应。方法将老年晚期非小细胞肺癌患者74例随机分为2组,对照组37例应用多西他赛+奥沙利铂方案连续化疗,观察组37例应用多西他赛+奥沙利铂方案的同时,给予消癌平注射液。观察2组患者近期疗效、生活质量、中位生存期及毒副反应。结果有效率观察组和对照组分别为32.4%和24.3%,差异有统计学意义(P<0.05);生活质量改善率观察组为75.6%,高于对照组的54.0%(P<0.05);中位生存期观察组388 d,长于对照组的243 d(P<0.05);毒副反应发生率观察组低于对照组(P<0.05)。结论消癌平注射液联合间断化疗治疗晚期非小细胞肺癌,可以提高患者的近期疗效、改善生存质量和延长生存期,安全性好。

Objective To evaluate the clinical efficacy and toxicities of xiaoaiping injection combined with intermittent chemotherapy for the elderly patients with advanced non-small cell lung cancer. Methods Seventy-four elderly patients with advanced non-small cell lung cancer were randomized into two groups： 37 patients of the control group received the continuous chemotherapy （docetaxel plus oxaliplatin）, and 37 patients of the treatment group received xiaoaiping injection and intermittent chemotherapy （docetaxel plus oxaliplatin）. The short term efficacy, quality of life, survival and toxicities were observed. Results In the treatment group and the control group, the re- sponse rate were 32.4% and 24.3% , the improvement rate of quality of life were 75.6% and 54.0% , the median survival time were 388 days and 243 days（P 〈 0.05） ; the incidence of toxicities of the treatment group were lower than those of the control group （ P 〈 0.05 ）. Conclusion Xiaoaiping injection combined with intermittent chemo- therapy is effective and safe for the elderly patients with advanced non-small cell lung cancer, and can improve the clinical efficacy, improve quality of life and lengthen survival time.