盐酸帕洛诺司琼在化疗性胃肠道反应防治中的应用

Value of Palonosetron Hydrochloride in the Prevention and Cure of Chemotherapy-related Gastrointestinal Reaction

目的探讨盐酸帕洛诺司琼在恶性肿瘤化疗患者胃肠道反应防治中的应用价值。方法入组147例接受化疗的恶性肿瘤患者,随机分为2组,观察组77例在接受化疗的同时给予盐酸帕洛诺司琼联合地塞米松预防胃肠道反应的发生,而对照组70例仅给予地塞米松进行预防。比较观察化疗1周内2组患者的胃肠道反应发生情况。结果观察组患者的症状完全控制率为81.8%(63/77),不完全控制率为18.2%(14/77),对照组分别为52.9%(37/70)、47.1%(33/70),2组比较差异有统计学意义(P<0.05)。结论盐酸帕洛诺司琼用于化疗性胃肠道反应的防治安全有效,有利于化疗的顺利进行。

Objective To investigate the value of palonosetron hydrochloride in the prevention and cure of chem- otherapy-related gastrointestinal reaction in patients with malignant tumor. Methods The 147 patients with malignant tumor received chemotherapy were randomly divided into 2 groups, 77 cases of the observation group received palonosetron hydrochloride and dexamethasone at the same time, while 70 cases of the control group received dexa- methasone. The gastrointestinal reaction of the 2 groups were observed comparatively. Results The symptoms com- pletely control rate of the observation group was 81. 8% （ 63/77 ）, the incomplete control rate was 18. 2% （ 14/77）, those of the control group were 52.9% （37/70） and 47.1% （ 33/70）, there was statistical significant difference between the 2 groups （P 〈 0.05）. Conclusion palonosetron hydrochloride is safe and effective in the prevention and cure of chemotherapy-related gastrointestinal reaction.