早产孕妇血浆纤维蛋白原、D二聚体水平变化及临床意义

The significance of the changes of fibrinogen and D-Dmier in premature pregnant women

目的探讨早产孕妇血浆纤维蛋白原（FIB）、D-二聚体（DID）水平变化及其临床意义。方法对132例早产孕妇（早产孕妇组）产前和产后（24h内）及60例健康非孕妇女（健康对照组）进行纤维蛋白原、D二聚体检测和分析。结果（1）早产孕妇产前的FIB显著高于健康对照组（P〈0．01）、D-D高于健康对照组（P〈0．05），差异有统计学意义；（2）与产前比较，产后FIB降低（P〈0．05），D-D显著增高（P〈0．01），差异有统计学意义。结论早产孕妇血液处于高凝、低纤溶状态，早产前后监测FIB、D-D水平对预防异常出血等产科并发症有重要的临床参考价值。

Objective To investigate the changes of fibrinogen （FIB） and D-Dmier（D-D） in premature preg nant women and its clinical significance. Methods 132 cases of premature pregnant women （premature woman group） before and after（within 24 hours） delivery and 60 cases of nonpregnant women （control group） were detected for FIB and D-D,To analyzer after detected. Results OThe concentration of FIB in premature pregnant women was obviously higher compared with the nonparturient women （P〈0.01） ,D-D was higher（P〈0.01） ,there were statistical differences; （2）Compared with before delivery, the concentration of FIB in premature pregnant women was low er （P〈0.05） after delivery, D-D was obviously higher（P〈0.01）, there were statistical differences. Conclusion Boold of premature pregnant women is in hypercoagulative state, Monitoring plasma FIB and D-D is helpful in predict abnormal bleeding and complications before and after delivery,which have important clinical reference value.