强化降糖治疗对老年2型糖尿病患者生活质量的影响

Effects of intensive blood glucose control on quality of life in elderly patients with type 2 diabetes

目的分析强化降糖治疗对老年2型糖尿病患者生活质量的影响。方法 97例老年2型糖尿病患者随机分为强化治疗组及标准治疗组,平均随访5年,随访中检测FBG、HbA1c等指标,填写欧洲五维度生活质量调查表(EQ-5D)并收集相关的研究结果。结果强化组与标准组相比生活质量及VAS评分均无显著性差异。Logistic回归分析显示,血管并发症、低血糖发作、女性、高龄、长病程、低教育程度及高体质量指数均显著影响糖尿病患者生活质量。结论强化降糖治疗对患者生活质量无显著影响,而血管并发症、低血糖发作显著降低患者生活质量,女性、高龄、病程长、受教育程度低及高体质量指数的患者生活质量更差,对这类患者应加强心理支持治疗。

Objective To investigate the effects of intensive blood glucose control on the quality of life of elderly patients with type 2 diabetes. Methods Ninety - seven elderly patients with type 2 diabetes were randomly assigned to intensive therapy group and standard therapy group. All patient had followed up for five years on average. The levels of fasting plasma glucose and hemoglobin A1 c were measured, and the outcomes were studied and European Quality of Life -5 Dimensions（ EQ -5D ） was collected during the regular follow - up. Results No significant difference was detected in all dimensions in quality of life, as well as in Visual Analog Scale score between two groups （ P 〉 0.05 ）. Results of The multivariate regression analysis showed that diabetic vascular complications, hypoglyeemic episodes, female, older age, longer disease course, less education, and higher body mass index （BMI） significantly affected QOL of the patients. （ P 〈 0.05）. Conclusion Intensive glucose control has no significant effect on QOL of the diabetic patients. Diabetic vascular complications and hypoglycemic episodes significantly affect QOL of the patients. Female, older age, long disease course, less education and high BMI are factors causing reduced QOL, and patients with these factors should be given more psychological support.