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Notch3信号通路与卵巢癌发生发展关系的研究 被引量：4

The mechanism of Notch3 mediated progression of ovarian cancer
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摘要 Notch信号传导通路是影响细胞命运的重要通路之一,相邻细胞间通过Notch受体传递信号可以调节多种细胞的分化、增殖和凋亡,影响器官形成和形态变化。Notch信号传导的变化与肿瘤的发生发展密切相关,如脑肿瘤、乳腺癌、肝癌等。近年来研究表明,Notch异常通路介导卵巢癌的发生发展,尤其Notch3及其信号传导分子参与肿瘤的化疗耐药与复发。文章对新近有关Notch3信号通路的重要分子调控卵巢癌的发生发展进行综述。 Notch signal pathway is one of crucial pathways related to cell fate determination, regulating cell differentiation, proliferation and apoptosis, with an effect of organ formation and morphogenesis. Abnormal activation of Notch gene occurs in many tumor cells, such as brain tumors, breast cancer and hepatoma. Recent studies have been found that the notch pathway out of control was related with growth of ovarian cancer. And Notch3 involving in the development and progression of ovarian cancer has been attracted extensive attention by experts and scholars. This review focuses on the literatures of Notch3 and related molecules regulating the development and progression of epithelial ovarian cancer.
作者 刘杨 杨恭 臧荣余
机构地区 复旦大学附属肿瘤医院妇瘤科 复旦大学附属肿瘤医院肿瘤研究所
出处 《中国癌症杂志》 CAS CSCD 北大核心 2013年第12期1001-1006,共6页 China Oncology
关键词 NOTCH3 卵巢癌 信号传导通路 Notch3 Epithelial ovarian cancer Signaling pathway
分类号 R737.31 [医药卫生—肿瘤]
  • 相关文献

参考文献43

  • 1MARKMAN M, MARKMAN J, WEBSTER K, et al. Duration of response to second-line, platinum-based chemotherapy for ovarian cancer: for patient management and clinical trial design [ J ]. J Clin Oncol, 2004, 22(15): 3120-3125.
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二级参考文献26

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共引文献24

同被引文献46

  • 1赵梅,韩伟.Notch信号传导通路相关疾病的研究进展[J].生物化学与生物物理进展,2006,33(12):1154-1160. 被引量：12
  • 2韦瑛,温冠媚.干细胞标志物研究[J].华夏医学,2007,20(1):166-168. 被引量：3
  • 3袁云.CADASIL的诊断与鉴别诊断[J].中国神经精神疾病杂志,2007,33(11):641-643. 被引量：48
  • 4Fernando HS, Sanders AJ, Kynaston HG, et al. WAVE1 is associated with invasiveness and growth of prostate cancer cells [J]. J Urol, 2008, 180(4):1515-1521.
  • 5Zhang J, Zhou S, Tang L, et al. WAVE1 gene silencing via RNA interference reduces ovarian cancer cell invasion, migra- tion and proliferation[J]. Gynecol Oncol, 2013, 130(2),354 -361.
  • 6Mcauliffe SM, Morgan SL, Wyant GA, et al. Targeting Notch, a key pathway for ovarian cancer stem ceils, sensitizes tumors to platinum therapy[J] Proc Natl Acad Sci U S A, 2012, 109(43): 2939-2948.
  • 7Gupta N, Xu Z, EI-Sehemy A, et al. Notch3 induces epithelial- mesenchymal transition and attenuates carboplatininduced apop-tosis in ovarian cancer cells[J]. Gynecol Oncol, 2013, 130(1) 200-206.
  • 8Kang H, Wang J, Sarah J, et al. Relativeactinnucleation pro- motion efficiency by WASP and WAVE proteins in endothelial cells[J]. Biochem Biophys Res Commun, 2010, 400(4):661- 666.
  • 9Steq AD, Katre AA, Goodman B, et al. Targeting the notch ligand JAGGED1 in both tumor cells and stroma in ovarian cancer[J]. ClinCancerRes, 2011, 17(17): 5674-5685.
  • 10Wang X, Gui L, Zhang Y, et al. Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF-β signaling pathway[J]. Int J Oneol, 2014, 44(4):1099- 1106.

引证文献4

二级引证文献7

中国癌症杂志
2013年 第12期

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