胃癌患者c-Met、AKT和VEGF的表达及临床意义

Expressions and clinical significance of c-Met,AKT and VEGF in patients with gastric cancer

目的探讨胃癌组织中c-Met、AKT和血管内皮生长因子(VEGF)的表达及意义。方法应用免疫组织化学法检测70例胃癌组织中c-Met、AKT和VEGF的表达,并分析其与临床病理特征的相关性。结果胃癌组织中c-Met、AKT和VEGF阳性表达率分别为21.4%(15/70)、37.1%(26/70)和11.4%(8/70)。c-Met表达与胃癌远处转移有关(P<0.05);AKT表达与胃癌分化程度、TNM分期、淋巴结转移、远处转移相关(P<0.05或P<0.01);而VEGF表达与胃癌分化程度相关(P<0.01)。c-Met与AKT和VEGF在胃癌组织中的表达呈正相关(r=0.319和r=0.250,P<0.01)。结论 c-Met、AKT和VEGF在胃癌中的阳性表达与胃癌的生物学行为密切相关。c-Met、AKT和VEGF之间可能存在协同作用,共同促进了胃癌的恶性发展。

Objective To investigate the expressions and clinical significance of c-Met, AKT and vascular endothelial growth factor （VEGF） in patients with gastric cancer. Methods The expressions of c-Met, AKT and VEGF were detected by immunohistochemitry in gastric cancer tissues of 70 cases, and the relationship between the expression and clinicopathological characteristics was analyzed. Results The positive rates of c-Met, AKT and VEGF in gastric cancer were 21.4% （15/70）, 37. 1% （26/70） and 11.4% （8/70）, respectively, c-Met expression showed a significant association with distant metastasis （P〈0. 05 ）. AKT expression had a close relation with tumor differentiation,TNM stage, lymph node metastasis and distant metastasis （P〈0. 05 or P〈0. 01）, while VEGF expression was only related to tumor differentiation （P〈0. 01 ）. Moreover, c-Met expression was positively correlated with AKT and VEGF in gastric cancer（r=0. 319 and 0. 250, P〈0. 01）. Conclusion The positive expressions of c-Met, AKT and VEGF are closely related to the biological behavior of gastric cancer. There may be a synergistic effect among c-Met, AKT and VEGF, which promotes the malignant development of gastric cancer.