摘要
目的探讨乳腺癌18 F-脱氧葡萄糖(18 F-FDG)摄取值与临床病理及生物指标的关联。方法回顾性分析20例乳腺癌患者的18F-FDG最大标准摄取值(SUVmax)与肿瘤大小、病理分级、雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体2(Her-2)和Ki-67表达之间的关系。结果瘤体直径与SUVmax值呈正相关(r=0.704,P<0.05)。13例高分化患者SUVmax值低于7例低分化患者(4.68±2.05vs.8.63±3.98)(P<0.05)。ER、PR和Her-2表达水平与SUVmax值无相关性(r=-0.092,r=-0.010和r=0.341,P>0.05),Ki-67表达水平与SUVmax值密切相关(r=0.483,P<0.05)。结论乳腺癌的病灶大小、病理分级和Ki-67表达与18 F-FDG摄取值密切相关;SUVmax在预后评估中有一定的临床应用价值。
Objective To investigate the relationship between the uptake value of 18 F fluorodeoxyglucose（18F-FDG） and clinicaopathology and biological indicators in the patients with breast cancer. Methods The relationship of the maximum standandized uptake value （SUVmax） of 18F-FDG with tumor size, tumor grade and expressions of estrogen receptor （ER）, progesterone receptor（PR） ,human epidermal receptor 2 （Her-2） and Ki-67 in 20 patients with breast cancer were retrospectively analyzed. Results SUV was positively correlated to the tumor diameter（r=0. 704, P〈0. 05）. SUVmax was higher in 13 patients with high differentiation than that in in 7 patients with low differentiation （4. 68 ± 2.05 vs. 8.63 ± 3. 98） （ P（0. 05 ）. There was no significant correlation between SUV,±x and the expressions of ER, PR and Her-2 （r=-0. 092, r=-0. 010 and r=0. 341, P〉0. 05）. The expression of Ki-67 was closely related to SUVmax （r=0. 483, P〈0. 05）. Conclusion The uptake value of 18F-FIX; is closely associated with tumor size, tumor grade and Ki-67 expression in patients with breast cancer. SUVmax can be taken as an indicator in evaluating the clinical prognosis of breast cancer.
出处
《江苏医药》
CAS
北大核心
2013年第24期2974-2976,共3页
Jiangsu Medical Journal
基金
国家自然科学基金青年基金(81202032)
