儿童青少年桥本甲状腺炎诊断和治疗

Diagnosis and management of Hashimoto's thyroiditis in children and adolescents

儿童青少年桥本甲状腺炎(HT)在临床上多以甲状腺肿及甲状腺功能低下相关症状起病,甲状腺功能检测结果不一,抗过氧化物酶抗体(TPOAb)是筛查HT最敏感的指标。随着病程进展,HT患儿的甲状腺功能逐渐恶化,其永久后遗症为甲状腺功能低下。儿童青少年HT的自然病史不甚明了,需长期密切监测及随访,甲状腺功能低下患儿需服用左旋甲状腺素治疗。

The most common clinical manifestations of Hashimoto＇s thyroiditis （HT） are goiter and hypothyroidism. The biochemical thyroid function varies quite widely among patients. Anti-TPO antibodies （TPOAbs） are the most sensitive index to screen HT. The thyroid function deteriorates gradually, and the hypothyroidism is the permanent sequeala of HT. The natural history of HT in children and adolescents is not fully known, and monitoring of thyroid function for all patients should be long-term. Children with hypothyroidism should he treated with levothyroxine replacement therapy.