血清上皮型脂肪酸结合蛋白与儿童肥胖、代谢综合征及其心血管危险因素的相关性研究

The association of epidermal fatty acid binding protein with obesity,metabolic syndrome and cardiovascular diseases in children

目的探讨血清上皮型脂肪酸结合蛋白(E-FABP)与肥胖儿童心血管疾病危险因素的相关性。方法入选30例代谢综合征(MS)儿童,32例非MS肥胖儿童以及50例正常对照儿童,检测并比较其E-FABP水平、糖脂代谢指标等的差异。结果与对照组相比较,MS组血清E-FABP水平升高,差异具有统计学意义(P=0.001);与非MS肥胖组相比,MS组血清E-FABP水平有升高趋势,但差异无统计学意义(P>0.05)。血清E-FABP水平与腰臀比、腰高比、动脉粥样硬化指数、空腹胰岛素、胰岛素抵抗指数呈正相关(P<0.05)。以E-FABP为自变量其余各指标为因变量,经多元逐步回归分析,影响儿童E-FABP水平的独立危险因素是动脉粥样硬化指数(P=0.018)。结论 E-FABP在肥胖和MS动脉粥样硬化的发生和发展过程中有一定的作用。

Objective To study the relationship between the level of serum epithelial fatty acid binding protein （E-FABP） and cardiovascular disease in obese children. Methods Thirty children with metabolic syndrome （MS）, 32 obesity children with no MS and 50 healthy children were recruited. Serum E-FABP and glucose/lipid metabolic indices were measured. Results Com-pared with the healthy children, levels of serum E-FABP in MS children were signiifcantly elevated （P=0.001）. Compared with obesity children, levels of serum E-FABP of MS children were elevated, but the difference was not signiifcant （P〉0.05）. The cor-relations of E-FABP with waist to hip ratio, waist-to-height ratio, atherogenic index, fasting insulin, insulin resistance index were positive （P〈0.05）. According to the multivariate stepwise regression analysis, E-FABP was the independent risk of atherogenic index （P=0.018）. Conclusions E-FABP plays a role in the development of atherosclerosis in obesity and MS.